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Professional paper - Review paper
Novosti u etiopatogenezi, dijagnostici i liječenju bolesnika s degenerativnim promjenama intervertebralnog diska slabinskog dijela kralježnice
Liječnički vjesnik, 143 (2021), 1-2; 63-77. https://doi.org/10.26800/LV-143-1-2-9
Grazio, Simeon; Grgurević, Lovorka; Perović, Darko; Schnurrer Luke Vrbanić, Tea; Kovač, Zdenko; Božić, Boris; Houra, Karlo; Borić, Igor; Kvesić, Dražen; Novak, Ruđer; Ferhatović Hamzić, Lejla; Grubišić, Frane; Sajko, Tomislav; Saftić, Robert; Dokuzović, Stjepan; Rotim, Krešimir More authors...

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Grazio, S., Grgurević, L., Perović, D., Schnurrer Luke Vrbanić, T., Kovač, Z., Božić, B. ... Rotim, K. (2021). Novosti u etiopatogenezi, dijagnostici i liječenju bolesnika s degenerativnim promjenama intervertebralnog diska slabinskog dijela kralježnice. Liječnički vjesnik, 143. (1-2), 63-77. doi: 10.26800/LV-143-1-2-9

Grazio, Simeon, et al. "Novosti u etiopatogenezi, dijagnostici i liječenju bolesnika s degenerativnim promjenama intervertebralnog diska slabinskog dijela kralježnice." Liječnički vjesnik, vol. 143, no. 1-2, 2021, pp. 63-77. https://doi.org/10.26800/LV-143-1-2-9

Grazio, Simeon, Lovorka Grgurević, Darko Perović, Tea Schnurrer Luke Vrbanić, Zdenko Kovač, Boris Božić, Karlo Houra, et al. "Novosti u etiopatogenezi, dijagnostici i liječenju bolesnika s degenerativnim promjenama intervertebralnog diska slabinskog dijela kralježnice." Liječnički vjesnik 143, no. 1-2 (2021): 63-77. https://doi.org/10.26800/LV-143-1-2-9

Grazio, S., et al. (2021) 'Novosti u etiopatogenezi, dijagnostici i liječenju bolesnika s degenerativnim promjenama intervertebralnog diska slabinskog dijela kralježnice', Liječnički vjesnik, 143(1-2), pp. 63-77. doi: 10.26800/LV-143-1-2-9

Grazio S, Grgurević L, Perović D, Schnurrer Luke Vrbanić T, Kovač Z, Božić B, and sur.. Novosti u etiopatogenezi, dijagnostici i liječenju bolesnika s degenerativnim promjenama intervertebralnog diska slabinskog dijela kralježnice. Liječnički vjesnik [Internet]. 2021 [cited 2024 April 19];143(1-2):63-77. doi: 10.26800/LV-143-1-2-9

S. Grazio, et al., "Novosti u etiopatogenezi, dijagnostici i liječenju bolesnika s degenerativnim promjenama intervertebralnog diska slabinskog dijela kralježnice", Liječnički vjesnik, vol. 143, no. 1-2, pp. 63-77, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:000156. [Accessed: 19 April 2024]

Metadata
Title (croatian)Novosti u etiopatogenezi, dijagnostici i liječenju bolesnika s degenerativnim promjenama intervertebralnog diska slabinskog dijela kralježnice
Title (english)Novelties in etiopathogenesis, diagnosis and treatment of patients with lumbar intevrertebral disc degeneration
AuthorSimeon Grazio
AuthorLovorka Grgurević
AuthorDarko Perović
AuthorTea Schnurrer Luke Vrbanić
AuthorZdenko Kovač
AuthorBoris Božić
AuthorKarlo Houra
AuthorIgor Borić
AuthorDražen Kvesić
AuthorRuđer Novak
AuthorLejla Ferhatović Hamzić
AuthorFrane Grubišić
AuthorTomislav Sajko
AuthorRobert Saftić
AuthorStjepan Dokuzović
AuthorKrešimir Rotim
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Anatomy and Clinical Anatomy)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Surgery)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pathophysiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathophysiology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Anatomy
Abstract (croatian)
Križobolja je jedan od najčešćih uzroka fizičke nesposobnosti, čije je najčešće izvorište degeneracija intervertebralnog diska. Nemogućnost točnog utvrđivanja potjecišta boli jest ograničavajući čimbenik u učinkovitijoj prevenciji i liječenju. Nova saznanja, napose u područjima genetike i analize proteina primjenom spektrometrije masa, bacaju novo svjetlo u razumijevanju etiopatogeneze degenerativne bolesti diska. Novim slikovnim metodama kao što je CEST magnetska rezonancija ili ADC magnetska rezonancija mogu se detektirati rane degenerativne promjene. Napredak je ostvaren glede razjašnjenja uloge fizičkog opterećenja, kao i tipa vježbi koje mogu imati utjecaj kako na razvoj tako i na liječenje bolesnika s degenerativnim promjenama diska. Na kraju, značajan napredak je ostvaren u kirurškom liječenju tih bolesnika, s naglaskom na minimalno invazivne tehnike. Ostali kirurški modaliteti liječenja su pokazali napredak koji ohrabruje, kao što su totalna zamjena diska i liječenje mezenhimalnim matičnim stanicama. Uz navedeno, i ostale novosti u dijagnostici i liječenju degenerativne bolesti vertebralnog diska raspravljene su u ovom članku.
Abstract (english)
Low-back pain is one of the most common causes of physical disability, most often originating from intervertebral disc degeneration. Lack of pinpointing the exact source of pain is the limiting factor in more efficient prevention and treatment. New findings, especially in the fields of genetics and mass spectometry based protein analysis, shed a new light to the understanding of etiopathogenesis of disc degenerative disease. New imaging methods like chemical exchange saturation transfer (CEST)MRI or apparent diffusion coefficient (ADC)MRI can detect early degenerative changes. Advances have been made regarding elucidating the role of physical load, as well as the type of exercise that can have an impact on the development and treatment of patients with degenerative disc disease. Finally, a significant progress has been made in the surgical treatment ecouraging of these patients, with an emphasis on minimally invasive techniques. Other surgical modalities have also shown improvement, like total disc replacement and mesenchymal stem cells treatments. These, and other novelties in the diagnosis and treatment of degenerative disc disease of lumbar spine are discussed in this article.
Keywords (croatian)
Keywords (english)
Languagecroatian
Languageenglish
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleLiječnički vjesnik
Numberingvol. 143, no. 1-2, pp. 63-77
p-ISSN0024-3477
e-ISSN1849-2177
DOIhttps://doi.org/10.26800/LV-143-1-2-9
URN:NBNurn:nbn:hr:105:000156
Publication2021
Document URLhttps://hrcak.srce.hr/253822
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2021-04-21 12:32:25