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master's thesis
Modeli za testiranje potencijalnih anksiolitika na "anksioznom" mišu in vivo
Zagreb: University of Zagreb, School of Medicine, 2020. urn:nbn:hr:105:392337
Petanjek, Tin Luka
University of Zagreb
School of Medicine
Department of Pharmacology

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Petanjek, T. L. (2020). Modeli za testiranje potencijalnih anksiolitika na "anksioznom" mišu in vivo (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:392337

Petanjek, Tin Luka. "Modeli za testiranje potencijalnih anksiolitika na "anksioznom" mišu in vivo." Master's thesis, University of Zagreb, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:105:392337

Petanjek, Tin Luka. "Modeli za testiranje potencijalnih anksiolitika na "anksioznom" mišu in vivo." Master's thesis, University of Zagreb, School of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:105:392337

Petanjek, T. L. (2020). 'Modeli za testiranje potencijalnih anksiolitika na "anksioznom" mišu in vivo', Master's thesis, University of Zagreb, School of Medicine, accessed 18 April 2024, https://urn.nsk.hr/urn:nbn:hr:105:392337

Petanjek TL. Modeli za testiranje potencijalnih anksiolitika na "anksioznom" mišu in vivo [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2020 [cited 2024 April 18] Available at: https://urn.nsk.hr/urn:nbn:hr:105:392337

T. L. Petanjek, "Modeli za testiranje potencijalnih anksiolitika na "anksioznom" mišu in vivo", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:105:392337

Metadata
TitleModeli za testiranje potencijalnih anksiolitika na "anksioznom" mišu in vivo
Title (english)Models for in vivo testing of potential anxiolytics in an "anxious" mouse
AuthorTin Luka Petanjek
MentorAnte Tvrdeić (mentor)
Committee memberPredrag Sikirić (predsjednik povjerenstva)
Committee memberJasenka Markeljević (član povjerenstva)
Committee memberAnte Tvrdeić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Zagreb
Defense date and country2020-07-17, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract
Anksiozni poremećaji smatraju se jednim od najčešćih duševnih poremećaja te se vjeruje da će velik dio populacije tijekom života ispuniti kriterije za barem jedan od anksioznih poremećaja. Karakterizirani su situacijski neprimjerenim strahom, panikom ili uz njih vezanim ponašanjem. Anksiozni poremećaji se međusobno razlikuju ovisno o situaciji u kojoj se pojavljuju ili simptomima koje iskazuju, te ih je moguće kategorizirati prema DSM-5 ili MKB-10 klasifikacijama. Smatra se kako do anksioznih poremećaja dolazi zbog disfunkcije u amigdala ili CSTC krugovima te njihovim neuronskim vezama s mnogim moždanim strukturama. Među neurotransmitere uključene u anksiozne poremećaje ubrajamo GABA-u, serotonin i kateholamine. Sustavi neurotransmitera ujedno su i cilj terapije anksioznih poremećaja te su danas najčešće upotrebljavani benzodiazepini, SSRI ili SNRI te buspiron čiji učinak je usmjeren na modulaciju, te spojevi s djelovanjem na periferne adrenergičke receptore koji imaju utjecaj na simptome anksioznih poremećaja. Kako bismo analizirali anksiozne poremećaje i uz njih vezane obrasce ponašanja te djelovanje farmakoloških pripravaka upotrebljavamo životinjske modele. Modele je potrebno vrjednovati kako bi se odredila njihova učinkovitost u analizi određenog poremećaja, djelovanja određenog anksiolitika ili primjenjivost opažanja u životinjskim modelima na ljude. U upotrebi su mnoge životinjske vrste poput štakora, miševa, zebra ribice i zamoraca, te razni oblici uređaja za testiranje.
Abstract (english)
Anxiety disorders are considered to be one of the most common mental disorders and it is believed that a large portion of the population will meet criteria for at least one anxiety disorder during their lifetime. They are characterized by situationally inappropriate fear, panic, or related behavior. Anxiety disorders differ from each other depending on the situation in which they occur or symptoms they exhibit and can be categorized according to DSM-5 or ICD-10 classifications. Anxiety disorders are thought to occur due to dysfunction in the amygdala or CSTC circuits and their neural connections to many brain structures. Neurotransmitters involved in anxiety disorders include GABA, serotonin, and catecholamines. Neurotransmitter systems are also the goal of anxiety disorder therapy. Today the most commonly used medicines are benzodiazepines, SSRIs or SNRIs and buspirone, whose effect is directed at modulation, and compounds with effects on peripheral adrenergic receptors that affect the symptoms of anxiety disorders. In order to analyze anxiety disorders and related behavioral patterns and the action of pharmacological agents, we use animal models. Models need to be evaluated to determine their effectiveness in analyzing a particular disorder, the action of a particular anxiolytic, or the applicability of observations in animal models to humans. Many animal species such as rats, mice, zebra fish and guinea pigs, and various forms of testing devices are in use.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:392337
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-08-24 09:04:28