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master's thesis
Promjene cirkadijanog ritma u štakorskom modelu sporadične Alzheimerove bolesti
Zagreb: University of Zagreb, School of Medicine, 2021. urn:nbn:hr:105:442725
Virag, Davor
University of Zagreb
School of Medicine
Department of Pharmacology

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Virag, D. (2021). Promjene cirkadijanog ritma u štakorskom modelu sporadične Alzheimerove bolesti (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:442725

Virag, Davor. "Promjene cirkadijanog ritma u štakorskom modelu sporadične Alzheimerove bolesti." Master's thesis, University of Zagreb, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:105:442725

Virag, Davor. "Promjene cirkadijanog ritma u štakorskom modelu sporadične Alzheimerove bolesti." Master's thesis, University of Zagreb, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:105:442725

Virag, D. (2021). 'Promjene cirkadijanog ritma u štakorskom modelu sporadične Alzheimerove bolesti', Master's thesis, University of Zagreb, School of Medicine, accessed 24 April 2024, https://urn.nsk.hr/urn:nbn:hr:105:442725

Virag D. Promjene cirkadijanog ritma u štakorskom modelu sporadične Alzheimerove bolesti [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2021 [cited 2024 April 24] Available at: https://urn.nsk.hr/urn:nbn:hr:105:442725

D. Virag, "Promjene cirkadijanog ritma u štakorskom modelu sporadične Alzheimerove bolesti", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:105:442725

Metadata
TitlePromjene cirkadijanog ritma u štakorskom modelu sporadične Alzheimerove bolesti
Title (english)Changes of the circadian rhythm in the rat model of sporadic Alzheimer's disease
AuthorDavor Virag
MentorMelita Šalković-Petrišić (mentor)
Committee memberNinoslav Mimica (predsjednik povjerenstva)
Committee memberJasenka Markeljević (član povjerenstva)
Committee memberMelita Šalković-Petrišić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Zagreb
Defense date and country2021-07-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Abstract
Promjene cirkadijanog ritma potencijalno imaju etiopatogenetsku ulogu u razvoju Alzheimerove bolesti koja još nije razjašnjena, a dodatni dijagnostički i terapijski potencijal leži u činjenici da se pojavljuju i prije nastupa kognitivnog deficita. Obrasci motoričke aktivnosti štakorskog modela sporadične Alzheimerove bolesti nakon intracerebroventrikularno primijenjenog streptozotocina (STZ-icv) ispitani su novom metodom, osmišljenom za neinvazivno i longitudinalno praćenje motorike laboratorijskih životinja. U odnosu na kontrole, u životinja tretiranih streptozotocinom prisutne su promjene cirkadijanog ritma u vidu povećane motoričke aktivnosti danju te smanjene aktivnosti tijekom noći, odnosno smanjenje cirkadijanih oscilacija motoričke aktivnosti već unutar 72 sata od druge primjene streptozotocina. Jedan od mogućih mehanizama nastanka ovog poremećaja je oštećenje hipotalamusa, glavnog regulatora cirkadijanog ritma. Oksidativni stres u hipotalamusu STZ-icv životinja ispitan je esejem tvari koje reagiraju s tiobarbiturnom kiselinom, kojim je nađen povećan stupanj lipidne peroksidacije u usporedbi s kontrolom. Ovi rezultati po prvi puta pokazuju prisutnost poremećaja cirkadijanog ritma u ranoj fazi razvoja fenotipa sporadične Alzheimerove bolesti u STZ-icv modelu i kao takvo posjeduje veliki potencijal za translaciju istraživanja u klinički kontekst.
Abstract (english)
Changes of the circadian rhythm have a potential etiopathogenetic role in the development of Alzheimer’s disease which has not yet been completely elucidated. Patterns of motor activity in the rat model of sporadic Alzheimer’s disease induced by intracerebroventricular application of streptozotocin (STZ-icv) were examined by a novel method, designed for noninvasive, continuous tracking of motor activity in test animals. For the first time, this research describes early changes of circadian rhythm in regards to increased activity by day, and reduced activity by night in animals treated with STZ-icv. One plausible mechanism of this disruption is increased oxidative stress in the hypothalamus, examined in this work by the thiobarbituric acid reactive substances assay. Circadian rhythm disruption in the early stages of Alzheimer’s disease phenotype progression in the STZ-icv model point to the importance of circadian rhythm as an etiopathogenetic factor of this disease, with great potential for research translation into a clinical context.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:442725
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-05-19 08:44:20