prikaz prve stranice dokumenta Comparison of Hemodiafiltration and Hemodialysis in Patients with End Stage Renal Disease
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master's thesis
Comparison of Hemodiafiltration and Hemodialysis in Patients with End Stage Renal Disease
Zagreb: University of Zagreb, School of Medicine, 2024. urn:nbn:hr:105:160957
Pohly, Nicola Michael Beat Willi
University of Zagreb
School of Medicine
Department of Internal Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Pohly, N. M. B. W. (2024). Comparison of Hemodiafiltration and Hemodialysis in Patients with End Stage Renal Disease (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:160957

Pohly, Nicola Michael Beat Willi. "Comparison of Hemodiafiltration and Hemodialysis in Patients with End Stage Renal Disease." Master's thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:160957

Pohly, Nicola Michael Beat Willi. "Comparison of Hemodiafiltration and Hemodialysis in Patients with End Stage Renal Disease." Master's thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:160957

Pohly, N. M. B. W. (2024). 'Comparison of Hemodiafiltration and Hemodialysis in Patients with End Stage Renal Disease', Master's thesis, University of Zagreb, School of Medicine, accessed 29 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:160957

Pohly NMBW. Comparison of Hemodiafiltration and Hemodialysis in Patients with End Stage Renal Disease [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2024 [cited 2024 November 29] Available at: https://urn.nsk.hr/urn:nbn:hr:105:160957

N. M. B. W. Pohly, "Comparison of Hemodiafiltration and Hemodialysis in Patients with End Stage Renal Disease", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:105:160957

Metadata
TitleComparison of Hemodiafiltration and Hemodialysis in Patients with End Stage Renal Disease
Title (croatian)Usporedba hemodijafiltracije i hemodijalize u pacijenata s terminalnom bubrežnom bolesti
AuthorNicola Michael Beat Willi Pohly
MentorIvica Horvatić (mentor)
Committee memberIvica Horvatić (predsjednik povjerenstva)
Committee memberJoško Mitrović (član povjerenstva)
Committee memberIvana Vuković Brinar (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Zagreb
Defense date and country2024-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
The most common and widely used form of dialysis is hemodialysis. Throughout time new forms of dialysis and combinations out of existing methods were invented. The problem is where do the newer methods like hemodiafiltration fit in and which niche could they conquer. This study is a single center, case control study in a group of 68 patients with end stage renal disease (45 patients on hemodialysis, 25 patients on hemodiafiltration). We present structured analysis of in total 47 parameters, of which 43 were deemed essential for dialysis control and 4 counted as addition for an overview of inflammatory and cardiovascular biomarkers. The results indicate that hemodialysis and hemodiafiltration performed in our Department are equal methods regarding removal of uremic toxins, showing no significant differences in clearance ratios. Major differences were observed in N-Terminal pro Brain-type Natriuretic Peptide, which showed an increased net filtration in the patients treated with hemodiafiltration compared to hemodialysis (p.adj = 0.00073). Out of 68 patients, 53 of them had relevant comorbidities (68.8% in hemodialysis group and 92.0% in hemodiafiltration group), with no statistically significant difference between the groups. Hemodiafiltration provides an alternative to hemodialysis regarding the removal of uremic toxins with similar clinical efficacy. There are potential benefits of performing hemodiafiltration in patients with end stage renal disease and comorbidities affecting the cardiovascular system compared to patients receiving hemodialysis. The outcome shown by NT-proBNP levels may lead to the suggestion that hemodiafiltration should be preferred in patients with active cardiovascular disease.
Abstract (croatian)
Najčešće korišteni oblik dijalize je hemodijaliza. Tijekom vremena razvijali su se novi oblici dijalize te kombinirale već postojeće metode. Postavlja se pitanje gdje smjestiti novije metode kao što je hemodijafiltracija te koji postojeći oblik dijalize bi one mogle zamijeniti. U ovom radu opisana je slučaj-kontrola studija u koju je uključeno 68 bolesnika s terminalnom bubrežnom bolesti liječenih dijalizom u KB Dubrava (45 bolesnika hemodijalizom, 25 bolesnika hemodijafiltracijom). Prikazani su podaci o ukupno 47 promatranih parametara od kojih se njih 43 smatra ključnim za kontrolu dijalize, a ostalih 4 pripada skupini inflamatornih i kardiovaskularnih biomarkera. Nakon analize dobijenih rezultata može se zaključiti kako su hemodijaliza i hemodijafiltracija u našoj ustanovi jednako uspješne metode za odstranjivanje uremijskih toksina (nije nađena statistički značajna razlika među klirensima). Najznačajnije razlike uočene su u koncentraciji NT-proBNP-a gdje se vidi veća neto filtracija kod bolesnika koji su liječeni hemodijafiltracijom u usporedbi s hemodijalizom (p.adj = 0.00073). Od ukupno 68 bolesnika njih 53 je imalo značajne komorbiditete (69.8% u skupini hemodijalize te 92.0% u skupini hemodijafiltracije), bez statistički značajne razlike između skupina. Hemodijafiltracija se pokazala kao alternativa hemodijalize s obzirom na uklanjanje uremijskih toksina s gotovo jednakim kliničkim ishodima. Postoje određene prednosti korištenja hemodijafiltracije kod bolesnika s terminalnom bubrežnom bolesti i komorbiditetima koji zahvaćaju srce i krvožilni sustav u usporedbi s hemodijalizom. Iz usporedbe razina NTproBNP- a može se zaključiti kako bi metoda izbora kod tih bolesnika možda trebala biti hemodijafiltracija.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:105:160957
Study programmeTitle: Medicine (in English language)
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-10-21 07:55:06