prikaz prve stranice dokumenta Comparison of systemic inflammatory response in patients with trochanteric region fracture fixation with Dynamic Hip Screw versus Proximal Femoral Nail
  Download
PDF 2.59 MB
doctoral thesis
Comparison of systemic inflammatory response in patients with trochanteric region fracture fixation with Dynamic Hip Screw versus Proximal Femoral Nail
Zagreb: University of Zagreb, School of Medicine, 2024. urn:nbn:hr:105:237796
Grezda, Kushtrim
University of Zagreb
School of Medicine
Department of Orthopedics

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Grezda, K. (2024). Comparison of systemic inflammatory response in patients with trochanteric region fracture fixation with Dynamic Hip Screw versus Proximal Femoral Nail (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:237796

Grezda, Kushtrim. "Comparison of systemic inflammatory response in patients with trochanteric region fracture fixation with Dynamic Hip Screw versus Proximal Femoral Nail." Doctoral thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:237796

Grezda, Kushtrim. "Comparison of systemic inflammatory response in patients with trochanteric region fracture fixation with Dynamic Hip Screw versus Proximal Femoral Nail." Doctoral thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:237796

Grezda, K. (2024). 'Comparison of systemic inflammatory response in patients with trochanteric region fracture fixation with Dynamic Hip Screw versus Proximal Femoral Nail', Doctoral thesis, University of Zagreb, School of Medicine, accessed 29 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:237796

Grezda K. Comparison of systemic inflammatory response in patients with trochanteric region fracture fixation with Dynamic Hip Screw versus Proximal Femoral Nail [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2024 [cited 2024 November 29] Available at: https://urn.nsk.hr/urn:nbn:hr:105:237796

K. Grezda, "Comparison of systemic inflammatory response in patients with trochanteric region fracture fixation with Dynamic Hip Screw versus Proximal Femoral Nail", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:105:237796

Metadata
TitleComparison of systemic inflammatory response in patients with trochanteric region fracture fixation with Dynamic Hip Screw versus Proximal Femoral Nail
Title (croatian)Usporedba sustavnoga upalnoga odgovora u bolesnika u kojih je prijelom u području trohantera saniran Dynamic Hip Screw ostecsintezom i onih liječenih Proximal Femoral Nail metodom
AuthorKushtrim Grezda
MentorMislav Jelić (mentor)
Committee memberTomislav Smoljanović (predsjednik povjerenstva)
Committee memberDomagoj Delimar (član povjerenstva)
Committee memberVedran Katavić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Orthopedics)
Zagreb
Defense date and country2024-10-22, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Orthopedics
Universal decimal classification
(UDC)		617 - Surgery. Orthopaedics. Ophthalmology
Abstract
Objective: This study aimed to investigate the differences in the early postoperative inflammatory response after treatment of trochanteric region fractures using a dynamic hip screw (DHS) compared with proximal femoral nail (PFN). Methods: In this prospective comparative study, 52 patients with Working Group for Osteosynthesis Problems (Ger. Arbeitsgemeinschaft für Osteosynthesefragen (AO))/The Orthopaedic Trauma Association (OTA) classification (AO/OTA) 31. A1–31.A2 pertrochanteric fractures were enrolled and allocated to one of two groups based on the treatment type: DHS group (n = 26, mean age = 78.9±7.1 years) and PFN group (n = 26, mean age = 79.4±7.2 years). Operation time was recorded in both groups. In each patient, circulating levels of interleukin-6 (IL-6), Creactive protein (CRP), and the erythrocyte sedimentation rate (ESR) were measured from blood samples collected 1 hour preoperatively and 24 hours postoperatively. Results: The operation time was slightly shorter in the PFN group than in the DHS group (38.3±15.9 and 51.2±22.1 min, respectively; P = 0.03). DHS and PFN both increased IL-6 (141.45±90.21 and 93.12±68.23 pg/mL, respectively), CRP (97.56±31.97 and 103.25±32.01 mg/L, respectively) levels, and the ESR (35.34±20.12 and 36.14±20.94 mm/h, respectively) 24 hours postoperatively. However, PFN compared to DHS resulted in a lesser increase from baseline to 24 hours postoperatively only in IL-6 (57.43±60.13 vs. 122.41±77.54 pg/mL, respectively; P = 0.011). Conclusion: The results of this study have shown that PFN induced a lower early postoperative inflammatory response, based on the assessment of IL-6, compared to DHS after surgical treatment of patients with pertrochanteric fractures.
Abstract (croatian)
Uvod: Cilj ovog istraživanja bio je istražiti razlike u indukciji ranog postoperativnog upalnog odgovora nakon liječenja pertrohanternih prijeloma dinamičkim vijkom kuka (DHS) ili proksimalnim femoralnim čavlom (PFN). Metode: 52 pacijenta s pertrohanternim prijelomima klasificiranim prema klasifikaciji radne skupine za osteosintezu (njem. Arbeitsgemeinschaft für Osteosynthesefragen (AO))/The Orthopaedic Trauma Association (OTA) classification (AO/OTA) 31.A1–31.A2) uključeno je u jednu od dvije skupine na temelju vrste liječenja: skupina DHS, i skupina PFN. Vrijeme operacije bilježeno je u obje skupine. Kod svakog pacijenta, cirkulirajuće razine interleukina-6 (hs-IL-6), Creaktivnog proteina (CRP), brzine sedimentacije eritrocita (ESR) mjerene su iz uzoraka krvi prikupljenih 1 sat prije operacije i 24 sata poslije operacije. Rezultati: Vrijeme operacije bilo je nešto kraće u skupini PFN nego u skupini DHS (38,3±15,9 odnosno 51,2±22,1 min; P = 0,03). DHS i PFN povećali su hs-IL-6 (141,45±90,21 odnosno 93,12±68,23 pg/mL), CRP (97,56±31,97 odnosno 03,25±32,01 mg/L) i ESR (35,34±20,12 odnosno 36,14±20,94 mm/h) 24 sata postoperativno. Zaključak: PFN inducira niži rani postoperativni upalni odgovor na temelju procjene hs-IL-6, u usporedbi s DHS u bolesnika s pertrohanternim prijelomima nakon liječenja.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:105:237796
Promotion2024
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Type of resourceText
Extent68 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Public noteKomentor: Cen Bytyqi
Created on2024-11-27 13:13:26