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undergraduate thesis
Protoonkogen RET i karcinomi štitnjače
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2020. urn:nbn:hr:159:270445
Vuković, Andro
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Biology and Microbial Genetics

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Vuković, A. (2020). Protoonkogen RET i karcinomi štitnjače (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:270445

Vuković, Andro. "Protoonkogen RET i karcinomi štitnjače." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2020. https://urn.nsk.hr/urn:nbn:hr:159:270445

Vuković, Andro. "Protoonkogen RET i karcinomi štitnjače." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2020. https://urn.nsk.hr/urn:nbn:hr:159:270445

Vuković, A. (2020). 'Protoonkogen RET i karcinomi štitnjače', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 09 December 2024, https://urn.nsk.hr/urn:nbn:hr:159:270445

Vuković A. Protoonkogen RET i karcinomi štitnjače [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2020 [cited 2024 December 09] Available at: https://urn.nsk.hr/urn:nbn:hr:159:270445

A. Vuković, "Protoonkogen RET i karcinomi štitnjače", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:159:270445

Metadata
TitleProtoonkogen RET i karcinomi štitnjače
Title (english)RET protooncogene and thyroid carcinoma
AuthorAndro Vuković
MentorReno Hrašćan (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Biology and Microbial Genetics)
Zagreb
Defense date and country2020-09-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Karcinom štitnjače najčešći je maligni endokrini tumor. Mnogo gena je uključeno u njegov nastanak, a jedan od njih je protoonkogen RET koji kodira za transmembranski receptor RET. Točkaste mutacije protoonkogena RET te njegove fuzije s različitim genima uzrokuju nastajanje mutiranog proteina RET. Kada se na mutirani protein RET vežu faktori rasta, pokreću se različiti signalni putevi kao što su MAPK i PI3K/Akt/mTOR signalni put, čija stalna aktivnost dovodi do nekontroliranog rasta stanica i inhibicije apoptoze te na taj način nastaje tumor. Ovi tumoria se dijagnosticiraju opipom i ultrazvukom, a njihovo liječenje se provodi operacijom, terapijom radioaktivnim jodom ili inhibitorima tirozin kinaza (TKI).
Abstract (english)
Thyroid carcinoma is the most common endocrine malignancy. Many genes are involved in its formation and one of them is RET protooncogene, which encodes a transmembrane receptor RET. Mutant protein RET is created by point mutations or RET fusions. Protein RET binding growth factors will cause abnormal activation of signal pathways, which include MAPK and PI3K/Akt/mTOR signal pathways. Their constant activity leads to uncontrollable cell growth, inhibition of apoptosis and tumour formation. Thyroid cancer diagnosis can be done by palpation or ultrasound and treatment options are operation, radioactive iodine therapy and thyroid kinase inhibitors (TKI).
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:270445
Study programmeTitle: Biotechnology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2020-10-20 08:42:14