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undergraduate thesis
Epigenetičko reprogramiranje spolnih prastanica
Zagreb: University of Zagreb, Faculty of Science, 2015. urn:nbn:hr:217:963293
Stipoljev, Sunčica
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Stipoljev, S. (2015). Epigenetičko reprogramiranje spolnih prastanica (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:963293

Stipoljev, Sunčica. "Epigenetičko reprogramiranje spolnih prastanica." Undergraduate thesis, University of Zagreb, Faculty of Science, 2015. https://urn.nsk.hr/urn:nbn:hr:217:963293

Stipoljev, Sunčica. "Epigenetičko reprogramiranje spolnih prastanica." Undergraduate thesis, University of Zagreb, Faculty of Science, 2015. https://urn.nsk.hr/urn:nbn:hr:217:963293

Stipoljev, S. (2015). 'Epigenetičko reprogramiranje spolnih prastanica', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 29 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:963293

Stipoljev S. Epigenetičko reprogramiranje spolnih prastanica [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2015 [cited 2024 November 29] Available at: https://urn.nsk.hr/urn:nbn:hr:217:963293

S. Stipoljev, "Epigenetičko reprogramiranje spolnih prastanica", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:217:963293

Metadata
TitleEpigenetičko reprogramiranje spolnih prastanica
Title (english)Epigenetic reprogramming in primordial germ cells
AuthorSunčica Stipoljev
MentorGordana Lacković-Venturin (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2015, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Epigenetski profil spolnih prastanica, koji je definiran modifikacijama DNA i kromatina, dinamično se mijenja za vrijeme njihovog razvoja. Dva puta u životnom ciklusu, metilacijski biljezi DNA se reprogramiraju na globalnoj razini i istodobno se obnavlja razvojni potencijal. Obrasci metilacije DNA su zatim ponovno uspostavljeni, u skladu sa različitim staničnim sudbinama. Ovo reprogramiranje metilacijskog obrasca DNA odvija se u zigoti nakon fertilizacije i u primordijalnim zametnim stanicama, koje su izravni preci spermija i oocita. U svakoj fazi reprogramiranja, jedinstveni set mehanizama regulira brisanje metilacije DNA i njezino ponovno uspostavljanje. Još nema istraživanja o potpunoj ontogenezi spolnih stanica u čovjeka i jako malo podataka je zabilježeno u vezi s kromatinskim promjenama i demetilacijom DNA u spolnim prastanicama. Doista, nije ustanovljen konačan redoslijed zbivanja ovih događaja u čovjeka (Leitch i sur., 2013).
Abstract (english)
The epigenetic profile of germ cells, which is defined by modifications of DNA and chromatin, changes dynamically during their development. At two points in the life cycle, DNA methylation marks are reprogrammed on a global scale, concomitant with restoration of developmental potency. DNA methylation patterns are subsequently re-established with the commitment towards a distinct cell fate. This reprogramming of DNA methylation takes place firstly on fertilization in the zygote, and secondly in primordial germ cells (PGCs), which are the direct progenitors of sperm or oocyte. In each reprogramming phase, a unique set of mechanisms regulates DNA methylation erasure and re-establishment. No studies are yet available on the full ontogeny of germline epigenetic reprogramming in the human and very few observations have been reported with regard to chromatin changes and DNA demethylation in PGCs. Indeed, a definitive timeline of when these events occur in humans has not been established (Leitch i sur., 2013).
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:963293
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2017-12-18 12:01:09