prikaz prve stranice dokumenta Učinak ponavljajuće transkranijske magnetske stimulacije H1 kacigom na beznađe u bolesnika s velikim depresivnim poremećajem
  Download
PDF 946.19 KB
doctoral thesis
Učinak ponavljajuće transkranijske magnetske stimulacije H1 kacigom na beznađe u bolesnika s velikim depresivnim poremećajem
Zagreb: University of Zagreb, School of Dental Medicine, 2024. urn:nbn:hr:127:651053
Gajšak, Tomislav
University of Zagreb
School of Dental Medicine
Chair of Psychiatry and Medical Psychology

Institutional repository: University of Zagreb School of Dental Medicine Repository

Cite this document

Gajšak, T. (2024). Učinak ponavljajuće transkranijske magnetske stimulacije H1 kacigom na beznađe u bolesnika s velikim depresivnim poremećajem (Doctoral thesis). Zagreb: University of Zagreb, School of Dental Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:127:651053

Gajšak, Tomislav. "Učinak ponavljajuće transkranijske magnetske stimulacije H1 kacigom na beznađe u bolesnika s velikim depresivnim poremećajem." Doctoral thesis, University of Zagreb, School of Dental Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:127:651053

Gajšak, Tomislav. "Učinak ponavljajuće transkranijske magnetske stimulacije H1 kacigom na beznađe u bolesnika s velikim depresivnim poremećajem." Doctoral thesis, University of Zagreb, School of Dental Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:127:651053

Gajšak, T. (2024). 'Učinak ponavljajuće transkranijske magnetske stimulacije H1 kacigom na beznađe u bolesnika s velikim depresivnim poremećajem', Doctoral thesis, University of Zagreb, School of Dental Medicine, accessed 20 March 2025, https://urn.nsk.hr/urn:nbn:hr:127:651053

Gajšak T. Učinak ponavljajuće transkranijske magnetske stimulacije H1 kacigom na beznađe u bolesnika s velikim depresivnim poremećajem [Doctoral thesis]. Zagreb: University of Zagreb, School of Dental Medicine; 2024 [cited 2025 March 20] Available at: https://urn.nsk.hr/urn:nbn:hr:127:651053

T. Gajšak, "Učinak ponavljajuće transkranijske magnetske stimulacije H1 kacigom na beznađe u bolesnika s velikim depresivnim poremećajem", Doctoral thesis, University of Zagreb, School of Dental Medicine, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:127:651053

Metadata
TitleUčinak ponavljajuće transkranijske magnetske stimulacije H1 kacigom na beznađe u bolesnika s velikim depresivnim poremećajem
Title (english)The effect of repetitive transcranial magnetic stimulation with H1 coil on hopelessness in patients with major depressive disorder
AuthorTomislav Gajšak
MentorZoran Zoričić (mentor)
Committee memberAna Matošić (predsjednik povjerenstva)
Committee memberZlatko Trkanjec (član povjerenstva)
Committee memberRudolf Gregurek (član povjerenstva)
GranterUniversity of Zagreb
School of Dental Medicine
(Chair of Psychiatry and Medical Psychology)
Zagreb
Defense date and country2024-10-22, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Universal decimal classification
(UDC)		616 - Pathology. Clinical medicine
Abstract
Cilj istraživanja bio je ispitati učinkovitost duboke ponavljajuće transkranijske magnetske stimulacije (dTMS) H1-zavojnicom uz standardnu terapiju beznađa kod velikog depresivnog poremećaja (VDP). Proveli smo randomizirano kontrolirano ispitivanje bez kontrole lažnom zavojnicom u tercijarnoj psihijatrijskoj ustanovi u Hrvatskoj na uzastopnom uzorku pacijenata s dijagnosticiranim velikim depresivnim poremećajem (VDP) bez psihotičnih simptoma i s klinički relevantnim beznađem. Intervencija je bila dTMS s H1-zavojnicom koja stimulira lijevi DLPFC visokom frekvencijom (18 Hz) tijekom četiri tjedna. Ishod je bio promjena rezultata Beckove ljestvice beznađa (engl. Beck Hopelessness Scale; BHS) u bolesnika predviđenih za liječenje (engl. intention-to-treat). Rezultati: Randomizirali smo 51 sudionika u intervencijsku skupinu (dTMS uz standardnu terapiju) i 52 u kontrolnu skupinu (uobičajeno liječenje). Prosječna dob bila je 50 (standardna devijacija; SD 12,3) godina i 50 (SD 10,4) godina, respektivno 47 % i 52 % žena. U bivarijatnoj, neprilagođenoj analizi razlika u smanjenju rezultata BHS-a bila je značajna (p = 0,043; stopa lažnog otkrića (FDR) > 5 %). U multivarijabilnoj analizi, rezultat BHS-a smanjen je za 10,8 % (95 % interval pouzdanosti (CI) -17,8 % do -3,9 %) u skupini s dTMS-om, a samo 0,7 % (95 % CI -7,5 % do 6,1 %) u kontrolnoj skupini (p=0,037; FDR < 5 %). Zaključci: Našli smo naznake učinka dTMS-a s H1-zavojnicom na simptom beznađa kod pacijenata dijagnosticiranih s VDP-om.
Abstract (english)
Aim: Assessment of the efficacy of deep repetitive transcranial magnetic stimulation (dTMS) with H1-coil augmented to standard therapy for hopelessness in major depressive disorder (MDD). Participants and methods: We performed a randomised controlled trial with no sham-coil at a tertiary psychiatric institution in Croatia in a consecutive sample of patients diagnosed with major depressive disorder (MDD) without psychotic symptoms and with clinically relevant hopelessness. The intervention was dTMS with H1-coil stimulating left DLPFC with high frequency (18 Hz) over four weeks. The outcome was a change in the Beck Hopelessness Scale (BHS) score in the intention-to-treat population. Results: We randomised 51 participants to the intervention group (dTMS augmented to standard therapy) and 52 to the control group (treatment as usual). The mean (SD) age was 50 (12.3), and 50 (10.4) years, 47 % and 52 % were women respectively. The difference in lowering of BHS score in bivariable, unadjusted analysis was significant (p = 0.043; false discovery rate (FDR) > 5 %). In multivariate analysis, the BHS score was reduced for 10.8 % (95 % confidence interval (CI) - 17.8 % to -3.9 %) in the dTMS, and only 0.7 % (95 % CI -7.5 % to 6.1 %) in the control group (p=0.037; FDR < 5 %). Conclusion: We have found an indication of the effect of dTMS with H1-coil on hopelessness symptom in patients diagnosed with MDD.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:127:651053
Promotion2024
Study programmeTitle: Dental medicine
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti u području biomedicine i zdravstva (doktor/doktorica znanosti u području biomedicine i zdravstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2024-10-31 08:12:24