prikaz prve stranice dokumenta Stability and structure of inclusion complexes of zaleplon with natural and modified cyclodextrins
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Stability and structure of inclusion complexes of zaleplon with natural and modified cyclodextrins
Croatica Chemica Acta, 84 (2011), 2; 169-178. https://doi.org/10.5562/cca1800
Jug, Mario; Gabričević, Mario; Weitner, Tin; Jablan, Jasna

Institucijski repozitorij: Repozitorij Farmaceutsko-biokemijskog fakulteta Sveučilišta u Zagrebu

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Jug, M., Gabričević, M., Weitner, T. i Jablan, J. (2011). Stability and structure of inclusion complexes of zaleplon with natural and modified cyclodextrins. Croatica Chemica Acta, 84. (2), 169-178. doi: 10.5562/cca1800

Jug, Mario, et al. "Stability and structure of inclusion complexes of zaleplon with natural and modified cyclodextrins." Croatica Chemica Acta, vol. 84, br. 2, 2011, str. 169-178. https://doi.org/10.5562/cca1800

Jug, Mario, Mario Gabričević, Tin Weitner i Jasna Jablan. "Stability and structure of inclusion complexes of zaleplon with natural and modified cyclodextrins." Croatica Chemica Acta 84, br. 2 (2011): 169-178. https://doi.org/10.5562/cca1800

Jug, M., et al. (2011) 'Stability and structure of inclusion complexes of zaleplon with natural and modified cyclodextrins', Croatica Chemica Acta, 84(2), str. 169-178. doi: 10.5562/cca1800

Jug M, Gabričević M, Weitner T, Jablan J. Stability and structure of inclusion complexes of zaleplon with natural and modified cyclodextrins. Croatica Chemica Acta [Internet]. 2011. [pristupljeno 23.11.2024.];84(2):169-178. doi: 10.5562/cca1800

M. Jug, M. Gabričević, T. Weitner i J. Jablan, "Stability and structure of inclusion complexes of zaleplon with natural and modified cyclodextrins", Croatica Chemica Acta, vol. 84, br. 2, str. 169-178, 2011. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:163:767001. [Citirano: 23.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:163:767001
Podaci o radu
Naslov (engleski)Stability and structure of inclusion complexes of zaleplon with natural and modified cyclodextrins
AutorMario Jug
AutorMario Gabričević
AutorTin Weitner
AutorJasna Jablan
Autorova ustanovaSveučilište u Zagrebu
Farmaceutsko-biokemijski fakultet
(Zavod za farmaceutsku tehnologiju)
Autorova ustanovaSveučilište u Zagrebu
Farmaceutsko-biokemijski fakultet
(Zavod za opću i anorgansku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Farmacija
Sažetak (engleski)
The interaction between zaleplon (ZAL) and different cyclodextrins in aqueous solutions was investigated by spectrofluorimetric and phase solubility studies. Stability constants determined by both methods showed that among natural cyclodextrins, β-cyclodextrin (βCD) formed the most stabile complex but its solubilizing efficiency was limited. Among βCD derivatives, the complex stability and solubilisation efficiency decreased in order: randomly methylated-βCD (RAMEB) > sulphobutylether-βCD (SBEβCD ) > hydroxypropyl-βCD (HPβCD). The inclusion complexes of ZAL with βCD and RAMEB were further characterised by 1H-NMR spectroscopy and the inclusion complex formation was confirmed in both cases. ROESY spectra showed two binding modes between ZAL and βCD which exist simultaneously in the solution. The first binding mode occurs by the inclusion of the phenyl ring of ZAL into the βCD central cavity via the wider rim of the cyclodextrin cone and is dominant. The second one is formed by the inclusion of pyrazolo[1,5-a]pyrimidine ring of ZAL.(doi: 10.5562/cca1800)
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatica Chemica Acta
Brojčani podacivol. 84, br. 2, str. 169-178
p-ISSN0011-1643
e-ISSN1334-417X
DOIhttps://doi.org/10.5562/cca1800
URN:NBNurn:nbn:hr:163:767001
Datum objave publikacije2011
URL dokumentahttps://hrcak.srce.hr/71979
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2020-04-17 16:36:04