Pharmacy is an important activity for people’s lives. The main task of pharmacy is to supply people with medicines and medical products in the most possible humane way, for the purpose of treatment, protection and prevention of disease. Economic development and the globalization of the market has led to changes in all industrial sectors, including pharmacy. New discoveries, technological development and new scientific methods are contributing to development of new medicines, but also the emergence of new diseases and extending the life expectancy, confronts pharmacists with new tasks whose aim is to find and produce more effective, safer and cheaper medicines. The pharmaceutical industry produces medicines, pharmaceuticals and other essential medical products for medical purposes. The medicines production process is a very expensive and rigorous procedure. With development of the economy and global progress, numerous regulatory and legal frameworks oriented on human rights, animal rights and the environment are emerging. It is not a rare case for some medicines to be withdrawn from the market, even after being commercialized, if there is any doubt that they can be harmful in any way. There are different points of view on pharmacy. From the economic point of view, pharmacy and investment in the pharmaceutical industry in recent years have seen an increase in revenues in the domestic and foreign markets, measured by economic indicators that are the subject of this paper, and those include: profit, earnings, expenses, liquidity, profitability and debt ratio. The aim of the paper is to present an economic analysis of the largest pharmaceutical companies in Croatia in order to determine the success of their business. The analysis was conducted on the basis of the available secondary data. The results and conclusions of the pharmaceutical industry are made by comparing the data.