The grapevine varieties used in the production of high quality brandy, are determined by specific characteristics: high total acidity, low sugar content and low pH. Several Croatian autochthonous varieties, like 'Kraljevina' and 'Ranfol', can be classified in the mentioned category. These varieties can be called potentially suitable for the production of wine brandies. The main aim of this research is to evaluate the characteristics of wine distillates obtained by ‘Kraljevina’ and ‘Ranfol’ varieties and to estimate their suitability for the production of wine brandies in climatic and pedological conditions in NW of the Republic of Croatia. Harvest and alcohol fermentation were carried out on the experimental vineyard called "Jazbina", and distillation in the laboratory of the Institute for Viticulture and Oenology of the Faculty of Agriculture in 2017. The analysis of the chemical composition of the wine, the analysis of the chemical composition of ‘the heart’ of crude distillates and the determination of the volatile compounds by gas chromatographic method, was performed. Conclusion is that the varieties 'Kraljevina' and 'Ranfol' contain the necessary characteristics that make them suitable for the production of wine brandies, according to the basic physico-chemical parameters determined in ‘the heart’ of the mentioned distillates. The given goal and obtained results have great importance to encourage the widespread use of these varieties for this purpose.