The skin is the largest organ on the body that has a protective, sensory, and regulatory function. With poor care and under the influence of various factors, the skin can be susceptible to various diseases. Although genetics regulate the development of organs, the phenotype of individuals is also influenced by external factors that can be crucial for the appearance of disease. Therefore, to carry out successful therapy, it is necessary to make a right diagnosis and find the causative agent. It is important to try to reduce the possibility of transmission of genetic causes of skin diseases to further offspring. Such methods can only be applied if we know the genetic background of the individual. The goal of every production, including horses are healthy, harmonious, hardy, and resistant animals that will produce the same offspring as they are. It is important that the horses are not suffering from any of the skin diseases, because this also means that their general health condition is impaired. There is a significant interest in horse exterior, especially those used for leisure and sport. More and more investments are being made in discovering, diagnosing, and implementing successful therapies in horse diseases.