This research is aimed at assessing the effectiveness of seed treatment and different genotypes of sugar beet in the control of two significant pests, the beet flea beetle (Chaetocnema tibialis Illiger 1807) and the sugar beet weevil (Bothynoderes punctiventris Germar 1824), in Croatia. Field experiments were conducted in the Vukovar-Syrmia County, specifically at the Ovčara and Bogdanovci locations, during the developmental stages of sugar beet from BBCH12 to BBCH31. The experiment included three different sugar beet genotypes and the following seed treatments: control (without insecticides), thiamethoxam + tau-fluvalinate, cyantraniliprole, teflutrin, and Beauveria bassiana + Metarhizium anisopliae. The research found that the genotype with rapid germination showed the highest susceptibility to damage from both pests, while the genotype with slow germination exhibited the least damage. Despite planting within the optimal timeframe, the results indicated that genotypes with faster germination were more vulnerable. The results demonstrate that treatments with thiamethoxam + teflutrin were highly effective only in mitigating pest damage during critical developmental stages. Current research suggests that numerous alternatives, some of which show promising effectiveness, have already been formulated. However, many of these alternatives may provide significant but potentially insufficient protection when used individually. Therefore, future strategies may be based on their combined integration within the framework of integrated pest management to achieve significant sugar beet protection. Experimental trials should be conducted to explore potential additive or synergistic effects to further enhance these approaches.