prikaz prve stranice dokumenta Detekcija visoko heterozigotnih regija u genomu goveda
  Download
PDF 2.95 MB
master's thesis
Detekcija visoko heterozigotnih regija u genomu goveda
Zagreb: University of Zagreb, Faculty of Agriculture, 2017. urn:nbn:hr:204:298634
Mercvajler, Mario
University of Zagreb
Faculty of Agriculture
Animal Science

Institutional repository: Repository Faculty of Agriculture University of Zagreb

Cite this document

Mercvajler, M. (2017). Detekcija visoko heterozigotnih regija u genomu goveda (Master's thesis). Zagreb: University of Zagreb, Faculty of Agriculture. Retrieved from https://urn.nsk.hr/urn:nbn:hr:204:298634

Mercvajler, Mario. "Detekcija visoko heterozigotnih regija u genomu goveda." Master's thesis, University of Zagreb, Faculty of Agriculture, 2017. https://urn.nsk.hr/urn:nbn:hr:204:298634

Mercvajler, Mario. "Detekcija visoko heterozigotnih regija u genomu goveda." Master's thesis, University of Zagreb, Faculty of Agriculture, 2017. https://urn.nsk.hr/urn:nbn:hr:204:298634

Mercvajler, M. (2017). 'Detekcija visoko heterozigotnih regija u genomu goveda', Master's thesis, University of Zagreb, Faculty of Agriculture, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:204:298634

Mercvajler M. Detekcija visoko heterozigotnih regija u genomu goveda [Master's thesis]. Zagreb: University of Zagreb, Faculty of Agriculture; 2017 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:204:298634

M. Mercvajler, "Detekcija visoko heterozigotnih regija u genomu goveda", Master's thesis, University of Zagreb, Faculty of Agriculture, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:204:298634

Metadata
TitleDetekcija visoko heterozigotnih regija u genomu goveda
Title (english)Detection of heterozygosity rich regions in cattle genome
AuthorMario Mercvajler
MentorMaja Ferenčaković (mentor)
Committee memberMaja Ferenčaković (predsjednik povjerenstva)
Committee memberIno Čurik (član povjerenstva)
Committee memberVlatka Čubrić Čurik (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Agriculture
(Animal Science)
Zagreb
Defense date and country2017-09-29, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Agronomy
Abstract
U posljednje vrijeme velik interes znanstvenika izazivaju “Runs of Homozygosity” (ROH) segmenti - kontinuirani dijelovi DNA nukleotidnog slijeda bez heterozigotnosti u diploidnom obliku. Nastaju kao posljedica uzgoja u srodstvu koji vodi do inbriding depresije, odnosno negativno utječe na “fitness” i proizvodna svojstva. Suprotno pojavi ROH-ova, u genomu se mogu naći „Heterozygosity rich regions“ (HRR) regije s visokim postotkom heterozigotnosti. Na uzorku od 120 Pinzgauer bikova genotipiziranih HD SNP čipom detektirano je 147126 HRR. Prosječna pokrivenost genoma HRR-ovima iznosila je 0,99% (0,57-1,13%). Detektirana su i 92 česta HRR-a (proporcija veća od 0,25) gdje je nađen ukupno 91 gen (78 s opisanom funkcijom). Funkcije nađenih gena su važne za biološke procese i pojave bolesti te imaju utjecaj na “fitness” jedinke. Ovo istraživanje, za razliku od prijašnjih istraživanja, preciznije detektira same HRR-ove i zasigurno će bit polazna točka za buduća istraživanja u ovom području.
Abstract (english)
Recently, scientists have been greatly interested in Runs of Homozygosity (ROH) segments - continuous parts of the DNA nucleotide sequence without heterozygosity in diploid state. They arise as a result of inbreeding that leads to inbreeding depression, ie negatively affecting the "fitness" and production properties. Contrary to the appearance of ROH, regions with a high percentage of heterozygosity can also be found in the genome - Heterozygosity Rich Regions (HRR). On the sample of 120 Pinzgauer bulls genotyped with HD SNP chip 147126 HRR were detected. The HRR average genome coverage was 0.99% (0.57-1.13%). 92 common HRR (proportion greater than 0.25) were detected, where a total of 91 genes (78 with the described function) were found. The functions of the discovered genes are important for biological processes and the occurrence of the disease and have an effect on the "fitness" of the individual. This research, unlike previous ones, detects HRRs more precisely and will certainly be the starting point for future research in this area.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:204:298634
Study programmeTitle: Animal Genetics and Breeding
Study programme type: university
Study level: graduate
Academic / professional title: magistar/ magistra inženjer/inženjerka genetike i oplemenjivanja životinja (magistar/ magistra inženjer/inženjerka genetike i oplemenjivanja životinja)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-12-01 13:41:24