The concept of regional development includes the process of initiating and encouraging the use of resources in the area of underdeveloped areas, and the goal of the process is to create sustainable overall economic development. The Republic of Croatia has conceived its own regional development strategy, which is crucial in the progress of prosperity in all its regions in order to reduce the gap between the national and the European Union average. It was noticed that in the Vukovar-Srijem County a few years ago there was a trend of total natural depopulation. Many business organizations have difficulties with their existence, which is why various ways should be devised to support their work. In the field of health care, it is necessary to reconstruct and equip all health care facilities. Due to the current trend of declining number of children in the education system, efforts are being made to adjust the education system with the help of professional staff and to modernize vocational education and harmonize it with the needs of the labor market. The need for new organizational forms in agricultural production has also been identified, and the wood industry requires better exploitation of locally available energy sources. The county has a large number of tourist attractions that need to be better valued and a large untapped potential related to hunting and hunting and religious tourism. In rural areas, the construction of new sports and recreation facilities is needed in order to revitalize these areas and to improve the overall economic picture of the county.