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undergraduate thesis
RNA interferencija u genskoj terapiji
Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology, 2018. urn:nbn:hr:181:636935
Mustač, Martina
Josip Juraj Strossmayer University of Osijek
Department of biology

Institutional repository: Repository of Department of biology, Josip Juraj Strossmayer University of Osijek

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Mustač, M. (2018). RNA interferencija u genskoj terapiji (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:181:636935

Mustač, Martina. "RNA interferencija u genskoj terapiji." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2018. https://urn.nsk.hr/urn:nbn:hr:181:636935

Mustač, Martina. "RNA interferencija u genskoj terapiji." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2018. https://urn.nsk.hr/urn:nbn:hr:181:636935

Mustač, M. (2018). 'RNA interferencija u genskoj terapiji', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:181:636935

Mustač M. RNA interferencija u genskoj terapiji [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology; 2018 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:181:636935

M. Mustač, "RNA interferencija u genskoj terapiji", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, Osijek, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:181:636935

Metadata
TitleRNA interferencija u genskoj terapiji
Title (english)RNA INTERFERENCE IN GENETIC THERAP
AuthorMartina Mustač
MentorIvna Štolfa Čamagajevac (mentor)
GranterJosip Juraj Strossmayer University of Osijek
Department of biology
Osijek
Defense date and country2018-09-13, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Male interferirajuće RNA (siRNA), RNA sa strukturom ukosnice (shRNA) i mikro RNA (miRNA) nekodirajuće su molekule koje imaju važnu ulogu u regulaciji ekspresije gena. Ove molekule se koriste kao posrednici u terapeutskom liječenju različitih bolesti kao što su infekcije i tumori. Sve tri molekule su dvolančane RNA molekule koje posredovanjem u procesu RNA interferencije rezultiraju utišavanjem gena komplementarnim sparivanjem s ciljnom mRNA molekulom. Ove se RNA molekule suočavaju sa sličnim preprekama tijekom RNAi: slaba stabilnost in vivo, poteškoće u isporuci molekule zbog barijera te neželjeni efekti koji ne rezultiraju utišavanjem gena. Najveći napredak u rješavanju tih nedostataka leži u dizajniranju sintetičkih molekula s poboljšanim karakteristikama, kemijskim modifikacijama te vektorima za isporuku molekula u ciljne stanice. Rezultati RNAi pokazuju da će terapije bolesti ovim metodama imati i široku primjenu u budućnosti
Abstract (english)
Small interfering RNA (siRNA), short hairpin RNA (shRNA) and micro RNA (miRNA) are non-coding molecules that play an important role in regulation of gene expression. These molecules are used as intermediates in the therapeutic treatment of various diseases such as infections and tumours. All three molecules are double-stranded RNA molecules that by mediating in the RNA interference process result in the suppression of the gene by complementary coupling with the target mRNA molecule. These RNA molecules face similar obstacles during RNAi: weak in vivo stability, difficulty in delivery of the molecule due to barrier, and unwanted effects that do not result in the suppression of the gene. The greatest advance in addressing these shortcomings lies in the design of synthetic molecules with improved characteristics, chemical modifications, and vector delivery molecules in the target ce
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:181:636935
Study programmeTitle: Undergraduate University Study Programme in Biology (Bachelor of Science)
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-01-23 12:38:26