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undergraduate thesis
Osobitosti toksičnosti paracetamola na modelima jetrenih stanica ljudi i štakora
Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology, 2019. urn:nbn:hr:181:119155
Nikolić, Josip
Josip Juraj Strossmayer University of Osijek
Department of biology

Institutional repository: Repository of Department of biology, Josip Juraj Strossmayer University of Osijek

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Nikolić, J. (2019). Osobitosti toksičnosti paracetamola na modelima jetrenih stanica ljudi i štakora (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:181:119155

Nikolić, Josip. "Osobitosti toksičnosti paracetamola na modelima jetrenih stanica ljudi i štakora." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2019. https://urn.nsk.hr/urn:nbn:hr:181:119155

Nikolić, Josip. "Osobitosti toksičnosti paracetamola na modelima jetrenih stanica ljudi i štakora." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2019. https://urn.nsk.hr/urn:nbn:hr:181:119155

Nikolić, J. (2019). 'Osobitosti toksičnosti paracetamola na modelima jetrenih stanica ljudi i štakora', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, accessed 29 December 2024, https://urn.nsk.hr/urn:nbn:hr:181:119155

Nikolić J. Osobitosti toksičnosti paracetamola na modelima jetrenih stanica ljudi i štakora [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology; 2019 [cited 2024 December 29] Available at: https://urn.nsk.hr/urn:nbn:hr:181:119155

J. Nikolić, "Osobitosti toksičnosti paracetamola na modelima jetrenih stanica ljudi i štakora", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, Osijek, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:181:119155

Metadata
TitleOsobitosti toksičnosti paracetamola na modelima jetrenih stanica ljudi i štakora
Title (english)CHARACTERISTICS OF PARACETAMOL TOXICITY IN HUMAN AND RAT HEPATIC CELL MODELS
AuthorJosip Nikolić
MentorMirta Sudarić Bogojević (mentor)
MentorMartina Smolić (komentor)
GranterJosip Juraj Strossmayer University of Osijek
Department of biology
Osijek
Defense date and country2019-09-13, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Paracetamol je lijek koji se koristi kao analgetik i antipiretik koji u preporučenim dozama nije štetan za organizam, a metabolizira se u jetri. U prekomjernim količinama je štetan zbog povećane koncentracije njegovog štetnog metabolita, NAPQI, čime se remeti elektron-transport lanac i povećava se produkcija reaktivnih kisikovih jedinki. U radu je provedeno istraživanje otpornosti dviju staničnih linija na povećane koncentracije paracetamola kroz različite vremenske periode: HTC (Hepatoma tissue culture), izolirane iz hepatokarcinoma štakora i Huh7, izolirane iz hepatokarcinoma čovjeka. Huh7 stanična linija pokazala je veću otpornost na toksičnost od HTC.
Abstract (english)
Paracetamol is an analgesic and antipyretic drug which is metabolized in the liver and it is not toxic in recommended doses. Overdose with paracetamol causes the formation of its reactive metabolite NAPQI which disrupts the electron transport and increases the production of reactive oxygen species. In this work, resistance to higher concentrations of paracetamols was observed between two cell lines through different periods of time: HTC (Hepatoma tissue culture), isolated from rat hepatoma and Huh7, isolated from human hepatoma. Huh7 has shown greater resistance to increased concentrations than HTC.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:181:119155
Study programmeTitle: Undergraduate University Study Programme in Biology (Bachelor of Science)
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2024-12-12
Terms of useLicence In copyright icon
Created on2019-12-12 11:50:30