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master's thesis
CITOSKELET NEURONA U MIŠEVA S NEDOSTATKOM B-SERIJE GANGLIOZIDA
Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology, 2022. urn:nbn:hr:181:857469
Kuzmanović, Adrian
Josip Juraj Strossmayer University of Osijek
Department of biology

Institutional repository: Repository of Department of biology, Josip Juraj Strossmayer University of Osijek

Cite this document

Kuzmanović, A. (2022). CITOSKELET NEURONA U MIŠEVA S NEDOSTATKOM B-SERIJE GANGLIOZIDA (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:181:857469

Kuzmanović, Adrian. "CITOSKELET NEURONA U MIŠEVA S NEDOSTATKOM B-SERIJE GANGLIOZIDA." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2022. https://urn.nsk.hr/urn:nbn:hr:181:857469

Kuzmanović, Adrian. "CITOSKELET NEURONA U MIŠEVA S NEDOSTATKOM B-SERIJE GANGLIOZIDA." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2022. https://urn.nsk.hr/urn:nbn:hr:181:857469

Kuzmanović, A. (2022). 'CITOSKELET NEURONA U MIŠEVA S NEDOSTATKOM B-SERIJE GANGLIOZIDA', Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:181:857469

Kuzmanović A. CITOSKELET NEURONA U MIŠEVA S NEDOSTATKOM B-SERIJE GANGLIOZIDA [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology; 2022 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:181:857469

A. Kuzmanović, "CITOSKELET NEURONA U MIŠEVA S NEDOSTATKOM B-SERIJE GANGLIOZIDA", Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, Osijek, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:181:857469

Metadata
TitleCITOSKELET NEURONA U MIŠEVA S NEDOSTATKOM B-SERIJE GANGLIOZIDA
Title (english)Neuron cytoskeleton in mice with b-series ganglioside deficiency
AuthorAdrian Kuzmanović
MentorSenka Blažetić (mentor)
MentorMarija Heffer (komentor)
Committee memberIrena Labak (predsjednik povjerenstva)
Committee memberValentina Pavić (član povjerenstva)
Committee memberMarija Heffer (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Department of biology
Osijek
Defense date and country2022-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Učinjena su histološka bojanja koronalnih prereza mozgova miševa s isključenim St8sia1 genom (KO) i miševa divljeg tipa (WT) kako bi se utvrdila tkivna raspodjela niza tvari unutar Cornu ammonis (CA) i Gyrus dentata (DG) regija hipokampusa. Analizom rezultata uočena je smanjena vaskularizacija CA3 regije hipokampusa miševa KO skupine u odnosu na miševe WT skupine. Nije uočena statistička značajna razlika u mitohondrijskoj aktivnosti između dvije skupine miševa. Manji intenzitet obojenja kolesterola unutar CA1 i CA2 regija hipokampusa te slabiji intenzitet obojenja za fosfolipide unutar CA1, CA2 i CA3 regija utvrđen je kod životinja KO skupine. U konačnici, utvrđen je statistički značajno veći intenzitet obojenja unutar CA1, CA3 i DG regija hipokampusa miševa KO skupine za aktinske mikrofilamente.
Abstract (english)
Histological staining methods were performed on coronal brain sections of St8sia1 knockout mice (KO) and compared to those of wild type mice (WT) to determine the distribution of several compounds within the Cornu ammonis (CA) and Gyrus dentata (DG) hippocampal regions. Analysis of the gathered results showed a reduced vascularization within the CA3 hippocampal region of the KO mouse group, compared to the WT. No statistically significant difference was observed in mitochondria activity between the two mouse groups. A reduced cholesterol staining was observed in the CA1 and CA2 hippocampal regions of the KO mouse group, as well as a reduced phospholipid staining in the CA1, CA2 and CA3 hippocampal regions. Finally, a higher actin filament staining was observed in the CA1, CA3 and DG regions of the KO mouse group.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:181:857469
Study programmeTitle: Master of Science Graduate University Study Programme in Biology; specializations in: Master of Biology
Course: Master of Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra biologije (magistar/magistra biologije)
Type of resourceText
File originBorn digital
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2022-07-25 10:47:18