prikaz prve stranice dokumenta Concurrent Elevations of VEGF, Osteopontin and MCP-1 Serum Levels Are Independent Predictors of Survival in Patients with Diffuse Large B-Cell Lymphoma
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Scientific paper - Original scientific paper
Concurrent Elevations of VEGF, Osteopontin and MCP-1 Serum Levels Are Independent Predictors of Survival in Patients with Diffuse Large B-Cell Lymphoma
Acta Haematologica, 136 (2016), 1; 52-61. https://doi.org/10.1159/000444624
Duletić-Načinović, Antica; Gačić, Vedrana; Valković, Toni; Lučin, Ksenija; Fišić, Elizabeta; Žuvić-Butorac, Marta; Seili-Bekafigo, Irena; Jonjić, Nives

Institutional repository: Repository of the University of Rijeka, Faculty of Biotechnology and Drug Development

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Duletić Načinović, A., Gačić, V., Valković, T., Lučin, K., Fišić, E., Žuvić Butorac, M. ... Jonjić, N. (2016). Concurrent Elevations of VEGF, Osteopontin and MCP-1 Serum Levels Are Independent Predictors of Survival in Patients with Diffuse Large B-Cell Lymphoma. Acta Haematologica, 136. (1), 52-61. doi: 10.1159/000444624

Duletić Načinović, Antica, et al. "Concurrent Elevations of VEGF, Osteopontin and MCP-1 Serum Levels Are Independent Predictors of Survival in Patients with Diffuse Large B-Cell Lymphoma." Acta Haematologica, vol. 136, no. 1, 2016, pp. 52-61. https://doi.org/10.1159/000444624

Duletić Načinović, Antica, Vedrana Gačić, Toni Valković, Ksenija Lučin, Elizabeta Fišić, Marta Žuvić Butorac, Irena Seili Bekafigo and Nives Jonjić. "Concurrent Elevations of VEGF, Osteopontin and MCP-1 Serum Levels Are Independent Predictors of Survival in Patients with Diffuse Large B-Cell Lymphoma." Acta Haematologica 136, no. 1 (2016): 52-61. https://doi.org/10.1159/000444624

Duletić Načinović, A., et al. (2016) 'Concurrent Elevations of VEGF, Osteopontin and MCP-1 Serum Levels Are Independent Predictors of Survival in Patients with Diffuse Large B-Cell Lymphoma', Acta Haematologica, 136(1), pp. 52-61. doi: 10.1159/000444624

Duletić Načinović A, Gačić V, Valković T, Lučin K, Fišić E, Žuvić Butorac M, and sur.. Concurrent Elevations of VEGF, Osteopontin and MCP-1 Serum Levels Are Independent Predictors of Survival in Patients with Diffuse Large B-Cell Lymphoma. Acta Haematologica [Internet]. 2016 May 10 [cited 2024 November 22];136(1):52-61. doi: 10.1159/000444624

A. Duletić Načinović, et al., "Concurrent Elevations of VEGF, Osteopontin and MCP-1 Serum Levels Are Independent Predictors of Survival in Patients with Diffuse Large B-Cell Lymphoma", Acta Haematologica, vol. 136, no. 1, pp. 52-61, May 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:193:136705. [Accessed: 22 November 2024]

Metadata
Title (english)Concurrent Elevations of VEGF, Osteopontin and MCP-1 Serum Levels Are Independent Predictors of Survival in Patients with Diffuse Large B-Cell Lymphoma
AuthorAntica Duletić-Načinović
AuthorVedrana Gačić
AuthorToni Valković
AuthorKsenija Lučin
AuthorElizabeta Fišić
AuthorMarta Žuvić-Butorac
AuthorIrena Seili-Bekafigo
AuthorNives Jonjić
Author's institutionUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract (english)
Background: Diffuse large B-cell lymphomas (DLBCL) are heterogeneous diseases, and the identification of additional DLBCL risk factors is especially important. Methods: In this pilot study, we determined pretreatment serum levels of vascular endothelial growth factor (VEGF), osteopontin (OPN) and macrophage chemotactic protein-1 (MCP-1) in 67 newly diagnosed DLBCL patients before treatment with standard chemoimmunotherapy and in 30 healthy persons. Results: Serum levels of all three cytokines were significantly elevated in untreated patients compared to controls. VEGF and OPN concentrations were higher in patients with advanced Ann Arbor stage, B symptoms, Eastern Cooperative Oncology Group score ≥2, International Prognostic Index (IPI) ≥3 and partial/no remission. A high MCP-1 level was associated with advanced stage, increased IPI and bone marrow infiltration. In univariate analysis, elevated OPN and VEGF, and concurrent elevation of all three biomarkers, were identified as significant predictors of poor survival. Multivariate Cox analysis revealed that elevated OPN combined with elevated VEGF levels was one of the best parameter subsets predicting poorest survival. Conclusion: According to our preliminary results, serum levels of VEGF and OPN before treatment predict response to therapy and survival after chemoimmunotherapy, and may help to further stratify DLBCL patients into risk groups.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionDraft version
Journal titleActa Haematologica
Numberingvol. 136, no. 1, pp. 52-61
p-ISSN0001-5792
e-ISSN1421-9662
DOIhttps://doi.org/10.1159/000444624
URN:NBNurn:nbn:hr:193:136705
Online first2016-05-10
Document URLhttps://www.karger.com/Article/Abstract/444624
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2018-09-30 10:02:45