prikaz prve stranice dokumenta Primjena peptidnog vezanja u sintezi odabranih 15^2-amino derivata klorina eˇ6
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master's thesis
Primjena peptidnog vezanja u sintezi odabranih 15^2-amino derivata klorina eˇ6
Rijeka: University of Rijeka, 2016. urn:nbn:hr:193:524352
Cvitan, Ana
University of Rijeka
Faculty of Biotechnology and Drug Development

Institutional repository: Repository of the University of Rijeka, Faculty of Biotechnology and Drug Development

Cite this document

Cvitan, A. (2016). Primjena peptidnog vezanja u sintezi odabranih 15^2-amino derivata klorina eˇ6 (Master's thesis). Rijeka: University of Rijeka. Retrieved from https://urn.nsk.hr/urn:nbn:hr:193:524352

Cvitan, Ana. "Primjena peptidnog vezanja u sintezi odabranih 15^2-amino derivata klorina eˇ6." Master's thesis, University of Rijeka, 2016. https://urn.nsk.hr/urn:nbn:hr:193:524352

Cvitan, Ana. "Primjena peptidnog vezanja u sintezi odabranih 15^2-amino derivata klorina eˇ6." Master's thesis, University of Rijeka, 2016. https://urn.nsk.hr/urn:nbn:hr:193:524352

Cvitan, A. (2016). 'Primjena peptidnog vezanja u sintezi odabranih 15^2-amino derivata klorina eˇ6', Master's thesis, University of Rijeka, accessed 30 December 2024, https://urn.nsk.hr/urn:nbn:hr:193:524352

Cvitan A. Primjena peptidnog vezanja u sintezi odabranih 15^2-amino derivata klorina eˇ6 [Master's thesis]. Rijeka: University of Rijeka; 2016 [cited 2024 December 30] Available at: https://urn.nsk.hr/urn:nbn:hr:193:524352

A. Cvitan, "Primjena peptidnog vezanja u sintezi odabranih 15^2-amino derivata klorina eˇ6", Master's thesis, University of Rijeka, Rijeka, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:193:524352

Metadata
TitlePrimjena peptidnog vezanja u sintezi odabranih 15^2-amino derivata klorina eˇ6
Title (english)Applications of peptide coupling to synthesis of selected 15^2-amino derivatives of chlorin eˇ6
AuthorAna Cvitan
MentorDavor Margetić (mentor)
Committee memberDavor Margetić (predsjednik povjerenstva)
Committee memberJasminka Giacometti (član povjerenstva)
Committee memberMladenka Malenica Staver (član povjerenstva)
GranterUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Rijeka
Defense date and country2016-09-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
U svrhu korištenja porfirinskih derivata u fotodinamičkoj terapiji sintetski je pripravljen 152-konjugat klorina e6 i 2-(2-piridil)etilamina. U ovisnosti o reakcijskim uvjetima i reagensima korištenim za peptidno vezanje, nastaju različite smjese u kojima dominira 152-konjugat, u odnosu na 152,173-biskonjugat. Reakcijski mehanizam njihova nastanka i reaktivnosti klorina e6 su diskutirani. Optimizacija reakcije dobivanja 131,152-anhidrida klorina e6 nije dovela do njegove priprave u čistom obliku pogodnom za korištenje za konjugaciju s aminima. Nadalje je pokazano kako direktna 152-konjugacija klorina e6 i triptamina peptidnim vezanjem dovodi do djelomičnog stvaranja produkta. Peptidno vezanje je također korišteno za pripravu novog 131-konjugata klorina e6 i triptofana a korištenjem reagensa za peptidno vezanje. Struktura novopripravljenog spoja je okarakterizirana 1D i 2D NMR (COSY i NOESY), UV/VIS i IR spektroskopijom, te masenom spektrometrijom. Analogna reakcija sa nikotinskom kiselinom nije bila uspješna.
Abstract (english)
For the purpose of use of porphyrin derivatives in photodynamic therapy, new 152-conjugate of chlorin e6 and 2-(2-pyridyl)ethylamine was prepared. Depending on reaction conditions and reagents used in peptide coupling, different mixtures were synthesized, with major product the 152-conjugate. In this master thesis reaction mechanism and reactivity of chlorine e6 is discussed. Optimization of synthesis of 131,152-chlorine e6 anhydride did not lead to its pure state appropriate for amine conjugation. Furthermore is shown that direct conjugation of 152-chlorine e6 and tryptamine by peptide coupling leads to partial product synthesis. Peptide coupling was also used for the preparation of new 131-chlorine e6 conjugate and tryptophan with application of peptide coupling reagents. New compound structure was characterized by 1D and 2D NMR (COSY and NOESY), UV/VIS and IR spectroscopy and also by mass spectrometry. Analogous reaction with nicotic acid was not successful.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:193:524352
Study programmeTitle: Medicinal chemistry
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra medicinske kemije (magistar/magistra medicinske kemije)
Type of resourceText
File originBorn digital
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2016-10-21 11:41:15