prikaz prve stranice dokumenta Glia in amyotrophic lateral sclerosis and spinal cord injury: common therapeutic targets
  Download
PDF 642.03 KB
Scientific paper - review paper
Glia in amyotrophic lateral sclerosis and spinal cord injury: common therapeutic targets
Croatian medical journal, 60 (2019), 2; 109-120. https://doi.org/10.3325/cmj.2019.60.109
Ban, Jelena; Mladinic, Miranda; Sámano, Cynthia; Munitic, Ivana

Institutional repository: Repository of the University of Rijeka, Faculty of Biotechnology and Drug Development

Cite this document

Ban, J., Mladinic, M., Sámano, C. & Munitic, I. (2019). Glia in amyotrophic lateral sclerosis and spinal cord injury: common therapeutic targets. Croatian medical journal, 60. (2), 109-120. doi: 10.3325/cmj.2019.60.109

Ban, Jelena, et al. "Glia in amyotrophic lateral sclerosis and spinal cord injury: common therapeutic targets." Croatian medical journal, vol. 60, no. 2, 2019, pp. 109-120. https://doi.org/10.3325/cmj.2019.60.109

Ban, Jelena, Miranda Mladinic, Cynthia Sámano and Ivana Munitic. "Glia in amyotrophic lateral sclerosis and spinal cord injury: common therapeutic targets." Croatian medical journal 60, no. 2 (2019): 109-120. https://doi.org/10.3325/cmj.2019.60.109

Ban, J., et al. (2019) 'Glia in amyotrophic lateral sclerosis and spinal cord injury: common therapeutic targets', Croatian medical journal, 60(2), pp. 109-120. doi: 10.3325/cmj.2019.60.109

Ban J, Mladinic M, Sámano C, Munitic I. Glia in amyotrophic lateral sclerosis and spinal cord injury: common therapeutic targets. Croatian medical journal [Internet]. 2019 April 30 [cited 2024 December 24];60(2):109-120. doi: 10.3325/cmj.2019.60.109

J. Ban, M. Mladinic, C. Sámano and I. Munitic, "Glia in amyotrophic lateral sclerosis and spinal cord injury: common therapeutic targets", Croatian medical journal, vol. 60, no. 2, pp. 109-120, April 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:193:669405. [Accessed: 24 December 2024]

Metadata
Title (english)Glia in amyotrophic lateral sclerosis and spinal cord injury: common therapeutic targets
AuthorJelena Ban
AuthorMiranda Mladinic
AuthorCynthia Sámano
AuthorIvana Munitic
Author's institutionUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Scientific / art field,
discipline and subdiscipline		INTERDISCIPLINARY AREAS OF KNOWLEDGE
Biotechnology in Biomedicine (natural science, biomedicine and healthcare, bioethics area
Abstract (english)
The toolkit for repairing damaged neurons in amyotrophic lateral sclerosis (ALS) and spinal cord injury (SCI) is extremely limited. Here, we reviewed the in vitro and in vivo studies and clinical trials on nonneuronal cells in the neurodegenerative processes common to both these conditions. Special focus was directed to microglia and astrocytes, because their activation and proliferation, also known as neuroinflammation, is a key driver of neurodegeneration. Neuroinflammation is a multifaceted process that evolves during the disease course, and can be either beneficial or toxic to neurons. Given the fundamental regulatory functions of glia, pathogenic mechanisms in neuroinflammation represent promising therapeutic targets. We also discussed neuroprotective, immunosuppressive, and stem-cell based approaches applicable to both ALS and SCI.
Keywords (english)
Languageenglish
Publication typeScientific paper - review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCroatian medical journal
Numberingvol. 60, no. 2, pp. 109-120
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2019.60.109
URN:NBNurn:nbn:hr:193:669405
Publication2019-04-30
Document URLhttp://www.cmj.hr/2019/60/2/31044582.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2019-09-09 14:20:48