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doctoral thesis
Proteini talini i KANK u fokalnim i retikularnim adhezijama posredovanim integrinom αVβ5 u stanicama melanoma MDA-MB-435S
Osjek: Josip Juraj Strossmayer University of Osijek, 2024. urn:nbn:hr:236:680373
Lončarić, Marija
Josip Juraj Strossmayer University of Osijek
Doctoral studies

Institutional repository: Repository of Doctoral School, Josip Juraj University in Osijek

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Lončarić, M. (2024). Proteini talini i KANK u fokalnim i retikularnim adhezijama posredovanim integrinom αVβ5 u stanicama melanoma MDA-MB-435S (Doctoral thesis). Osjek: Josip Juraj Strossmayer University of Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:236:680373

Lončarić, Marija. "Proteini talini i KANK u fokalnim i retikularnim adhezijama posredovanim integrinom αVβ5 u stanicama melanoma MDA-MB-435S." Doctoral thesis, Josip Juraj Strossmayer University of Osijek, 2024. https://urn.nsk.hr/urn:nbn:hr:236:680373

Lončarić, Marija. "Proteini talini i KANK u fokalnim i retikularnim adhezijama posredovanim integrinom αVβ5 u stanicama melanoma MDA-MB-435S." Doctoral thesis, Josip Juraj Strossmayer University of Osijek, 2024. https://urn.nsk.hr/urn:nbn:hr:236:680373

Lončarić, M. (2024). 'Proteini talini i KANK u fokalnim i retikularnim adhezijama posredovanim integrinom αVβ5 u stanicama melanoma MDA-MB-435S', Doctoral thesis, Josip Juraj Strossmayer University of Osijek, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:236:680373

Lončarić M. Proteini talini i KANK u fokalnim i retikularnim adhezijama posredovanim integrinom αVβ5 u stanicama melanoma MDA-MB-435S [Doctoral thesis]. Osjek: Josip Juraj Strossmayer University of Osijek; 2024 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:236:680373

M. Lončarić, "Proteini talini i KANK u fokalnim i retikularnim adhezijama posredovanim integrinom αVβ5 u stanicama melanoma MDA-MB-435S", Doctoral thesis, Josip Juraj Strossmayer University of Osijek, Osjek, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:236:680373

Metadata
TitleProteini talini i KANK u fokalnim i retikularnim adhezijama posredovanim integrinom αVβ5 u stanicama melanoma MDA-MB-435S
Title (english)Talin and KANK proteins in integrin αVβ5 mediated focal and reticular adhesions in melanoma cell line MDA-MB-435S
AuthorMarija Lončarić
MentorAndreja Ambriović Ristov (mentor)
Committee memberIgor Weber (predsjednik povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
(Doctoral studies)
Osjek
Defense date and country2024-07-03, Croatia
Scientific / art field,
discipline and subdiscipline		INTERDISCIPLINARY AREAS OF KNOWLEDGE
Biotechnology in Biomedicine (natural science, biomedicine and healthcare, bioethics area
Universal decimal classification
(UDC)		61 - Medical sciences
Abstract
Stanice melanoma MDA-MB-435S tvore fokalne (FA) i retikularne adhezije (RA) posredovane integrinom αVβ5. Utišavanje integrina αV povećava osjetljivost stanica melanoma MDA-MB-435S na protutumorski lijek paklitaksel te smanjuje učinkovitost migracije. U ovom radu pokazali smo da je prekid funkcionalne veze proteina talina 2 iz FA i KANK2 iz kortikalnog kompleksa za stabilizaciju mikrotubula mehanizam kojim stanice postaju osjetljivije na paklitaksel, upućujući da su talin 2 i KANK2 potencijalne mete u liječenju melanoma. Analizirali smo RA stanica MDA-MB-435S i utvrdili da je KANK2, uz talin2, sastavnica RA.
Abstract (english)
Melanoma cell line MDA-MB-435S forms integrin αVβ5 mediated focal (FA) and reticular adhesions (RA). Knockdown of integrin αV increases the sensitivity of MDA-MB-435S cells to the microtubule-targeting antitumor drug paclitaxel and reduces migration. In this work, we showed that the mechanism of these effects is mediated by the binding of talin 2 from FA and KANK2 from the cortical microtubule stabilizing complex. We identified talin 2 as a potential target in tumor therapy. We analyzed RA in MDA-MB-435S cells and discovered KANK2 as a new component of RA.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:236:680373
Promotion2024
Study programmeTitle: University Postgraduate Interdisciplinary Doctoral Study Molecular Biosciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti (doktor/doktorica znanosti)
Type of resourceText
Extent199
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-07-24 07:34:30