Big Data was a key driver for the development of many IT directions for analyzing this type of data. Predictive analytics enables linking data from different sources, such as databases, Web data, ATMs, textual data (notes from call centers or medical records). The latest methods for analysis of business data can provide reliable conclusions about the current situation and future events that might occur. Business analytics can help high management of company to make the right decisions and take timely and correct actions. Beside predictive analytics, systems of cognitive computing are getting much more attention too. They learn, understand and solve very complex problems that human brain can not solve in such short time as computer program can. The main objective of this thesis is to research all opportunities of new technology trends and the world examples and apply new knowledge to the current system of Croatian Healthcare. Taking in consideration that Croatia is a small country and researched technology is still young and at the very beginning, metodology applied in this thesis is deductive methodology which generates individual conclusions (Croatian market) from general facts (world examples). Based on existing data and facts, it can be concluded that the Croatian health system has a good IT foundation for the development of predictive analytics and application in the real sector. From the national strategy and proposal for the health development in the next 5 years, it can be concluded that informatization of healthcare system is developing in this direction. The first step will be the implementation of electronic medical records system, and in a long-term period it will become basis for the development of cognitive computing.