The concept of resilience today is one of the most important concepts in the modern social sciences. The results of research dealing with individual resilience open up many possibilities for the development of evidence-based interventions. The primary focus of this paper is on the synthesis of the results of numerous studies, both domestic and foreign, which dealt with individual resilience factors in order to provide practical guidelines for creating evidence-based preventive interventions, ie guidelines for effective and scientific prevention of behavioral problems in children and young people. The most important individual resilience factors are: (1) quality and attached relationship with a parent or any other competent adult, (2) self-regulation, (3) problem-solving skills, (4) positive self-image (which includes self-esteem and self-efficacy), (5) autonomy, (6) self-awareness, (7) commitment to school and academic success (focus on achievement in general). These factors need to be implemented in preventive interventions according to the gender and age of the target population, as well as according to the context in which they will be implemented. Encouraging the development of individual resilience of each child and young person is an effective, and increasingly popular, in behavioral problems prevention, but also in ensuring overall healthy development and positive developmental outcomes of children and young people. In addition, it represents a process that encourages the effective mobilization of all available resources at a number of different levels.