The purpose of this thesis is to gain insight into the employment and work of persons with disabilities in the circumstances of the COVID-19 pandemic. Current regulations in the field of employment of persons with disabilities are presented and an insight is provided into the possibilities, rights and obligations of persons with disabilities, as well as employers who employ persons with disabilities. All persons with disabilities have the right to equal conditions and opportunities, as well as the right to equal participation in society and to live without barriers. There are many benefits to working, such as financial security and independence, developing your own skills and competencies, improving your self-confidence and developing a sense of contribution to society. The coronavirus pandemic has posed a number of challenges to national and global economies. It has affected the whole society and all citizens, especially the marginalized groups of society to which persons with disabilities belong. People with disabilities face a number of obstacles and challenges in meeting their own needs. One of the biggest challenges faced by people with disabilities is hiring and maintaining existing employment. The entire population, and especially people with disabilities, is facing numerous changes in the way of working and the way of employment, reduced working hours and teleworking. Therefore, this thesis presents the adopted recommendations and measures for the protection of persons with disabilities, as well as recommendations for work and preservation of jobs in the circumstances of the COVID-19 virus pandemic. With the impact of the COVID-19 pandemic in the Republic of Croatia, the paper presents research on the experiences and employment of people with disabilities during the pandemic in the United States, Canada, the United Kingdom, and developing countries such as Argentina and Jordan. The COVID-19 pandemic opens up numerous opportunities for remote work for the entire population. Teleworking could have a positive effect on the work and employment of people with disabilities in the future and could lead employers to start valuing employees on the basis of their knowledge, experience and skills, rather than on the need to adapt.