Communication disorders are most commonly diagnosed in childhood. The most common communication disorder, autism spectrum disorder (ASD) is a neurodevelopmental disorder with difficulties in social communication and interaction and atypicalities in the characteristics of general behavior and interests. Numerous studies have established a significantly higher level of stress in parents of children with PSA compared to parents of children without developmental difficulties, as well as in comparison to parents of children with other developmental disorders. Mindfulness based clinical interventions have become increasingly popular in the last thirty years among the population of parents of children with communication disorders. A concept closely related to mindfulness, but still insufficiently researched on the mentioned population is the concept of compassion, especially self-compassion. Hence, the purpose of this research was to examine the relationship between self-compassion and psychological well-being of parents of preschool children with communication disorders. The research was conducted electronically, and 39 participants (37 women and 2 men), aged 29 to 51, took part. The questionnaire package included questionnaire about general informations, Children Behaviour Checklist (CBCL), Questionnaire for measuring stressors and intensity of parental stress (UIIRS), Compassionate Engagement and Action Scale; subscale Self-Compassion (CEAS), Depression Anxiety Stress Scales (DASS-21) and Warwick-Edinburgh Mental Wellbeing Scales (WEMWBS). The results of the research indicate that parents of children with communication disorders show higher levels of self-compassion compared to the levels established by foreign research on the general population. A moderate level of positive mental health was established, as well as an elevated level of mental health problems. The negative association between children's behavioral problems and parents' psychological well-being was also confirmed. Self-compassion is positively related to positive mental health and is a significant independent predictor of positive mental health. This research found no significant association of self-compassion with mental health problems. The obtained results suggest that self-compassion plays an important role in the psychological well-being of parents of children with communication disorders, and point to the importance of further research into this concept.