Mindfulness meditation is known as a meditative technique that improves attention and conscious focus through targeted attention, in the moment here and now, without judgment. Its benefits have been recognized since the past, when the Mindfulness Based Stress Reduction program was founded in application with people suffering from chronic diseases, while further various studies have shown improvements in psychophysiological and general functioning in people with chronic diseases. Some of the advantages of mindfulness meditation are its easy availability, cost-effectiveness and possible application in all environments, without the necessary need to adjust the environment. Chronic diseases have been on the rise in recent years, and they imply conditions that last three months or more. The long duration of the disease, the symptoms and consequences that come with the disease affect both the physical and mental health of a person. Therefore, it is important to react and enable patients to maintain their quality of life, and the application of mindfulness meditation has so far obtained positive results in working with adolescents and adults. The most commonly applied interventions within mindfulness are Mindfulness Based Stress Reduction (MBSR) and Mindfulness Based Cognitive Therapy (MBCT). Based on the above, the aim of this work is to consider the impact of mindfulness on the psychophysical status of people suffering from various chronic diseases through a systematic literature review. For this purpose, a review of scientific research available in databases such as Hrčak, Google Scholar, PubMed, Scopus, Ebsco, etc. was presented. The obtained results showed that mindfulness interventions can have a positive effect on supporting physical and mental health, improving the quality of life and self-regulation in people with chronic diseases. Also, it is necessary to do further research in order to define the specific approaches and methodology of applying different mindfulness interventions in relation to the characteristic needs and conditions of people suffering from a wide range of chronic diseases.