Oncological diseases are one of the leading causes of mortality in the world and represent a significant public health problem due to their complexity and diversity. Despite advances in diagnosis and treatment, cancer patients often face severe psychological and physical challenges that affect their overall recovery and quality of life. Considering the complexity of the consequences of oncological diseases, a holistic approach to patients and inclusion in various therapeutic techniques is needed. One of the approaches that has shown significant effectiveness in the field of coping with stress and supporting quality of life is mindfulness. In this sense, the goal of this work was defined, which was related to the examination of the influence of mindfulness on the psychophysical status of patients with malignant diseases, with special reference to the research methodology, applied mindfulness techniques and the duration of involvement in the therapeutic program. For this purpose, a review of scientific research available in databases such as Hrčak, Google Scholar, PubMed, Scopus, Ebsco, etc. was carried out. The obtained research results indicate the benefits of applying mindfulness in encouraging positive changes in the physiological and psychosocial responses of an individual. Mindfulness techniques, which include meditation, conscious breathing and yoga, provide patients with tools for better emotional regulation and coping with illness. Mindfulness can significantly reduce stress and depression levels in cancer patients, thereby improving their ability to cope with the emotional challenges that accompany the disease. Likewise, practicing the mindfulness technique can improve the physical status of patients in a way that reduces symptoms of fatigue and improves the quality of sleep. Through meditation and conscious breathing techniques, patients can shift their focus from stressful stimuli and pain to moments of peace and presence, which significantly contributes to their overall well-being. The obtained knowledge confirms that the integration of mindfulness techniques with standard therapeutic interventions can provide significant benefits, but further research is needed to enable a more detailed analysis and design of therapeutic protocols adapted to the specific and individual needs of oncology patients.