Goldenhar syndrome is characterized by a triad of defects: eye and/or ear anomaly, craniofacial anomaly and vertebral anomaly. Aforementioned anomalies may also be accompanied by an impaired functioning of other systems such as cardiovascular or gastrointestinal system. Prevalence of this syndrome ranges from 1:3500 to 1:7000 and it occurs more frequently with males (the ratio of 3:2). Considering the syndrome’s characteristics, possible difficulties may occur in communication, language and speech development. The purpose of this paper is to present the effects of communication and language stimuli with a two-year-old baby girl with Goldenhar syndrome after the initial development assessment established an uneven profile with the strongest variances in communication and language and speech development. Speech language pathological guidance was arranged during a seven-month period and was directed towards communication development as well as language comprehension and production in everyday situations and routines relying on the child’s interests and applying efficient strategies for stimulating young children. The girl’s communicative functions and means were monitored in accordance to Pragmatics Profile of Everyday Communication Skills in Children, while the language and speech development was monitored once a month via Communication Development Inventories (KORALJE) carried out by girl’s mother. Before commencing and at the end of the work, the girl was questioned with the help of Reynell Developmental Language Scales, while at the end of the assistance the Croatian versions of Peabody Picture Vocabulary Test (PPVT-III-HR) were also carried out. At the end of speech language pathological guidance, the girl showed an improvement in a number of communicative functions and means, in language comprehension and production as well as in playing games. The contribution of this paper is in presenting difficulties that may occur in development of children with Goldenhar syndrome, as well as in presenting stimuli for communication and language and speech development with young children. The research conducted demonstrates the importance of timely identification of communication and/or language and speech development difficulties with children suffering from various medical conditions, as well as the importance of inclusion into intervention programmes directed at both the child and its family.