Since they greatly determine human behavior, interests have been attracting the attention of researchers for more than a century. Interests of persons with autism spectrum disorder (ASD) are particularly compelling because they differ in their intensity and focus from interests of neurotypical persons. These special interests are one of the important criteria for establishing a diagnosis of ASD. The aim of this research was to assess content and intensity of interests of preschool children with ASD and to compare the obtained results with current scientific data. Preschool Children’s Interests Questionnaire used in the research was completed by the parents of 56 preschool children with ASD. The results revealed the children show equally high interest for animate and inanimate aspects of environment, although means of transportation and vehicles stand out as an area of special interest on various items of the questionnaire. A high interest of children for electronics was also reported, despite the unexpectedly small amount of time children spent using electronic devices. Data obtained in this research point to partial agreement with current scientific data, but nevertheless support the notion special interests are a clinically significant feature of ASD that should be taken into consideration when developing intervention.