Epidermolysis bullosa is a group of rare hereditary skin diseases characterized by skin hypersensitivity and blister formation in the areas of skin exposed to rubbing. In addition to physical manifestation, the disease is characterized by secondary complications on numerous organs and organ systems. Due to its complex diagnosis, which results in the everyday confrontation with various challenges and demands, this disease has a significant influence on the psychosocial and emotional status of the affected person. In addition to the need for social support and the support of family members, the treatment requires the involvement of a multidisciplinary care team, which should provide appropriate psychosocial support to the patients. Given the complex clinical picture, the biopsychosocial model represents the best form of therapeutic intervention in treatment and rehabilitation of this incurable disease. The aim of this paper was to show the impact of the work of the educational rehabilitator on the quality of life of people affected by epidermolysis bullosa, and to demonstrate in which way the educational rehabilitation approach, as one of the holistic approaches within the biopsychosocial model can affect personal development and well-being of the affected person, thus consequently improving his daily functioning in the environment as well as his quality of life. Scientific literature data and research results, which indicate the influence of using creative and expressive media such as music, dance and movement or psychodrama on psychosocial difficulties, adaptation and confrontation with epidermolysis bullosa, are scarce but point to scientific foundation and efficiency of creative and art/expressive therapies in the treatment of people affected by epidermolysis bullosa.