The focus of this research is to examine the relationship between resilience and humor in families of children with disabilities and to find out how parents of children with disabilities define humor, in which family situations they use humor, how they relate/ associate humor and difficulties, and what role humor plays in their family. 39 parents of children with disabilities were interviewed and 5 interviewed. A demographic questionnaire, a combination of two scales: The Coping Humor Scale (CHS; Martin and Lefcourt, 1983) and The Humor Orientation Scale (HOC; Steven and Melanie Booth-Butterfield, 1991 Martin and Lefcourt, 1984) and the Family Resilience Assessment Questionnaire (FRAS, Ferić, Maurović, and Žižak, 2016) were used as the measuring instruments of the quantitative part of the research. Using humor as a coping strategy has been shown to reduce the level of family connection. Considering demographic factors, it has been found that with increasing age of parents decreases the overall use of humor, and with increasing age of the child increases the use of humor as a coping strategy. It has been shown that the greater the number of children in the family, parents are more likely to use humor as a coping strategy. In processing the qualitative part of the research, humor functions and interview questions were used from the Families ’Function of Humor (Rieger and College, 2004). Qualitative data analysis revealed that parents of children with disabilities recognize the importance of humor in their family's lives. They think that humor has the role of building an optimistic mindset, they use humor as a way of communication, a way of connecting with one another and connecting with the community. The findings also show that they use humor as a tool in relieving stress, solving problems and revealing a playful spirit within themselves in the context of their family's difficulties.