prikaz prve stranice dokumenta Absence of Oral Opportunistic Infections in Patients with Inflammatory Bowel Disease Receiving Anti-TNF-α and Anti-Integrin-α4β7 Therapy
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Scientific paper - Original scientific paper
Absence of Oral Opportunistic Infections in Patients with Inflammatory Bowel Disease Receiving Anti-TNF-α and Anti-Integrin-α4β7 Therapy
Dentistry Journal, 10 (2022), 3; 32. https://doi.org/10.3390/dj10030032
Saltović, Ema; Mijandrušić-Sinčić, Brankica; Braut, Alen; Škrobonja, Ivana; Sever, Ella; Glažar, Irena; Pezelj-Ribarić, Sonja; Muhvić-Urek, Miranda

Institutional repository: Repository of the University of Rijeka, Faculty of Dental Medicine

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Saltović, E., Mijandrušić Sinčić, B., Braut, A., Škrobonja, I., Sever, E., Glažar, I. ... Muhvić Urek, M. (2022). Absence of Oral Opportunistic Infections in Patients with Inflammatory Bowel Disease Receiving Anti-TNF-α and Anti-Integrin-α4β7 Therapy. Dentistry Journal, 10. (3). doi: 10.3390/dj10030032

Saltović, Ema, et al. "Absence of Oral Opportunistic Infections in Patients with Inflammatory Bowel Disease Receiving Anti-TNF-α and Anti-Integrin-α4β7 Therapy." Dentistry Journal, vol. 10, no. 3, 2022. https://doi.org/10.3390/dj10030032

Saltović, Ema, Brankica Mijandrušić Sinčić, Alen Braut, Ivana Škrobonja, Ella Sever, Irena Glažar, Sonja Pezelj Ribarić and Miranda Muhvić Urek. "Absence of Oral Opportunistic Infections in Patients with Inflammatory Bowel Disease Receiving Anti-TNF-α and Anti-Integrin-α4β7 Therapy." Dentistry Journal 10, no. 3 (2022). https://doi.org/10.3390/dj10030032

Saltović, E., et al. (2022) 'Absence of Oral Opportunistic Infections in Patients with Inflammatory Bowel Disease Receiving Anti-TNF-α and Anti-Integrin-α4β7 Therapy', Dentistry Journal, 10(3). doi: 10.3390/dj10030032

Saltović E, Mijandrušić Sinčić B, Braut A, Škrobonja I, Sever E, Glažar I, and sur.. Absence of Oral Opportunistic Infections in Patients with Inflammatory Bowel Disease Receiving Anti-TNF-α and Anti-Integrin-α4β7 Therapy. Dentistry Journal [Internet]. 2022 February 23 [cited 2024 April 29];10(3). doi: 10.3390/dj10030032

E. Saltović, et al., "Absence of Oral Opportunistic Infections in Patients with Inflammatory Bowel Disease Receiving Anti-TNF-α and Anti-Integrin-α4β7 Therapy", Dentistry Journal, vol. 10, no. 3, February 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:271:863437. [Accessed: 29 April 2024]

Metadata
Title (english)Absence of Oral Opportunistic Infections in Patients with Inflammatory Bowel Disease Receiving Anti-TNF-α and Anti-Integrin-α4β7 Therapy
AuthorEma Saltović
AuthorBrankica Mijandrušić-Sinčić
AuthorAlen Braut
AuthorIvana Škrobonja
AuthorElla Sever
AuthorIrena Glažar
AuthorSonja Pezelj-Ribarić
AuthorMiranda Muhvić-Urek
Author's institutionUniversity of Rijeka
(Faculty of Dental Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Oral Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Biological therapy of inflammatory bowel disease (IBD) carries an increased risk for the development of opportunistic infections due to immunomodulation. The aim of this study was to determine the prevalence and types of oral infections in IBD patients treated with biological (anti-TNF-α and anti-integrin-α4β7) and conventional medication protocols. The study included 20 IBD patients receiving anti-TNF-α therapy, 20 IBD patients receiving anti-integrin-α4β7 therapy and 20 IBD patients without immunomodulatory therapy. Participants completed questionnaires on medical information, oral lesions and symptoms. For each patient, clinical examination and a salivary flow rate test were performed, followed by a swab of the oral mucosa. The swab samples were cultured to identify Candida spp. and oral bacteria. No bacterial opportunistic infections were detected. Candidiasis was detected in four participants, with no significant difference between groups (p = 0.765). Hyposalivation was most common in the anti-TNF-α group, with a significant difference between groups (p = 0.036). There were no significant differences between groups in self-reported oral mucosal lesions and symptoms (p > 0.05), or in the distribution of oral mucosal lesions (p > 0.05). This study suggests that IBD patients receiving biological therapy are at no greater risk of developing oral opportunistic infections than IBD patients not receiving immunomodulatory therapy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleDentistry Journal
Numberingvol. 10, no. 3, 32
e-ISSN2304-6767
DOIhttps://doi.org/10.3390/dj10030032
URN:NBNurn:nbn:hr:271:863437
Publication2022-02-23
Document URLhttps://www.mdpi.com/2304-6767/10/3/32
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-01-19 08:17:04