prikaz prve stranice dokumenta Biomolecules in Dental Applications: Randomized, Controlled Clinical Trial Evaluating the Influence of Hyaluronic Acid Adjunctive Therapy on Clinical Parameters of Moderate Periodontitis
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Scientific paper - Original scientific paper
Biomolecules in Dental Applications: Randomized, Controlled Clinical Trial Evaluating the Influence of Hyaluronic Acid Adjunctive Therapy on Clinical Parameters of Moderate Periodontitis
Biomolecules, 11 (2021), 10; 1491. https://doi.org/10.3390/biom11101491
Olszewska-Czyz, Iwona; Kralik, Kristina; Prpić, Jelena

Institutional repository: Repository of the University of Rijeka, Faculty of Dental Medicine

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Olszewska Czyz, I., Kralik, K. & Prpić, J. (2021). Biomolecules in Dental Applications: Randomized, Controlled Clinical Trial Evaluating the Influence of Hyaluronic Acid Adjunctive Therapy on Clinical Parameters of Moderate Periodontitis. Biomolecules, 11. (10). doi: 10.3390/biom11101491

Olszewska Czyz, Iwona, et al. "Biomolecules in Dental Applications: Randomized, Controlled Clinical Trial Evaluating the Influence of Hyaluronic Acid Adjunctive Therapy on Clinical Parameters of Moderate Periodontitis." Biomolecules, vol. 11, no. 10, 2021. https://doi.org/10.3390/biom11101491

Olszewska Czyz, Iwona, Kristina Kralik and Jelena Prpić. "Biomolecules in Dental Applications: Randomized, Controlled Clinical Trial Evaluating the Influence of Hyaluronic Acid Adjunctive Therapy on Clinical Parameters of Moderate Periodontitis." Biomolecules 11, no. 10 (2021). https://doi.org/10.3390/biom11101491

Olszewska Czyz, I., Kralik, K. and Prpić, J. (2021) 'Biomolecules in Dental Applications: Randomized, Controlled Clinical Trial Evaluating the Influence of Hyaluronic Acid Adjunctive Therapy on Clinical Parameters of Moderate Periodontitis', Biomolecules, 11(10). doi: 10.3390/biom11101491

Olszewska Czyz I, Kralik K, Prpić J. Biomolecules in Dental Applications: Randomized, Controlled Clinical Trial Evaluating the Influence of Hyaluronic Acid Adjunctive Therapy on Clinical Parameters of Moderate Periodontitis. Biomolecules [Internet]. 2021 [cited 2024 November 22];11(10). doi: 10.3390/biom11101491

I. Olszewska Czyz, K. Kralik and J. Prpić, "Biomolecules in Dental Applications: Randomized, Controlled Clinical Trial Evaluating the Influence of Hyaluronic Acid Adjunctive Therapy on Clinical Parameters of Moderate Periodontitis", Biomolecules, vol. 11, no. 10, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:271:067440. [Accessed: 22 November 2024]

Metadata
Title (english)Biomolecules in Dental Applications: Randomized, Controlled Clinical Trial Evaluating the Influence of Hyaluronic Acid Adjunctive Therapy on Clinical Parameters of Moderate Periodontitis
AuthorIwona Olszewska-Czyz
AuthorKristina Kralik
AuthorJelena Prpić
Author's institutionUniversity of Rijeka
(Faculty of Dental Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Periodontology
Abstract (english)
The biological activity of hyaluronic acid (HA) has been well-researched during the past decades ; however, there are few randomized, controlled trials of its clinical effects in periodontal therapy. The purpose of this study was to evaluate the effect of hyaluronic acid on the principal parameters of periodontal healing. A specific, commercially available formulation designed and registered for professional dental application, composed of 16 mg/mL of cross-linked and 2 mg/mL of non-cross-linked HA, was used as an adjunctive to non-surgical periodontal therapy, and clinical parameters were evaluated after 3 months. The addition of HA to periodontal therapy demonstrated more favorable clinical results regarding reduction in inflammation, measured by bleeding on probing (−6% compared to the control group) and gain in periodontal attachment (1 mm more than control group), while it had no effect on probing depth reduction. No side effects were reported. Our study demonstrated that HA is a safe and easy-to-use biological agent ; due to its wide array of properties, it may significantly improve the results of periodontal therapy. However, more long-term studies are needed to investigate whether these favorable effects remain over time.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBiomolecules
Numberingvol. 11, no. 10, 1491
p-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom11101491
URN:NBNurn:nbn:hr:271:067440
Publication2021
Document URLhttp://bib.irb.hr/1224264
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-01-23 07:49:15