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Scientific paper - Original scientific paper
A Histologic, Histomorphometric, and Immunohistochemical Evaluation of Anorganic Bovine Bone and Injectable Biphasic Calcium Phosphate in Humans: A Randomized Clinical Trial
International Journal of Molecular Sciences, 24 (2023), 6; 1-19. https://doi.org/10.3390/ijms24065539
Tomas, Matej; Karl, Matej; Čandrlić, Marija; Matijević, Marko; Juzbašić, Martina; Peloza, Olga Cvijanović; Radetić, Ana Terezija Jerbić; Kuiš, Davor; Vidaković, Bruno; Ivanišević, Zrinka; Kačarević, Željka Perić

Institutional repository: Repository of the University of Rijeka, Faculty of Dental Medicine

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Tomas, M., Karl, M., Čandrlić, M., Matijević, M., Juzbašić, M., Peloza, O. C. ... Kačarević, Ž. P. (2023). A Histologic, Histomorphometric, and Immunohistochemical Evaluation of Anorganic Bovine Bone and Injectable Biphasic Calcium Phosphate in Humans: A Randomized Clinical Trial. International Journal of Molecular Sciences, 24. (6), 1-19. doi: 10.3390/ijms24065539

Tomas, Matej, et al. "A Histologic, Histomorphometric, and Immunohistochemical Evaluation of Anorganic Bovine Bone and Injectable Biphasic Calcium Phosphate in Humans: A Randomized Clinical Trial." International Journal of Molecular Sciences, vol. 24, no. 6, 2023, pp. 1-19. https://doi.org/10.3390/ijms24065539

Tomas, Matej, Matej Karl, Marija Čandrlić, Marko Matijević, Martina Juzbašić, Olga Cvijanović Peloza, Ana Terezija Jerbić Radetić, et al. "A Histologic, Histomorphometric, and Immunohistochemical Evaluation of Anorganic Bovine Bone and Injectable Biphasic Calcium Phosphate in Humans: A Randomized Clinical Trial." International Journal of Molecular Sciences 24, no. 6 (2023): 1-19. https://doi.org/10.3390/ijms24065539

Tomas, M., et al. (2023) 'A Histologic, Histomorphometric, and Immunohistochemical Evaluation of Anorganic Bovine Bone and Injectable Biphasic Calcium Phosphate in Humans: A Randomized Clinical Trial', International Journal of Molecular Sciences, 24(6), pp. 1-19. doi: 10.3390/ijms24065539

Tomas M, Karl M, Čandrlić M, Matijević M, Juzbašić M, Peloza OC, and sur.. A Histologic, Histomorphometric, and Immunohistochemical Evaluation of Anorganic Bovine Bone and Injectable Biphasic Calcium Phosphate in Humans: A Randomized Clinical Trial. International Journal of Molecular Sciences [Internet]. 2023 [cited 2024 November 22];24(6):1-19. doi: 10.3390/ijms24065539

M. Tomas, et al., "A Histologic, Histomorphometric, and Immunohistochemical Evaluation of Anorganic Bovine Bone and Injectable Biphasic Calcium Phosphate in Humans: A Randomized Clinical Trial", International Journal of Molecular Sciences, vol. 24, no. 6, pp. 1-19, 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:271:555353. [Accessed: 22 November 2024]

Metadata
Title (english)A Histologic, Histomorphometric, and Immunohistochemical Evaluation of Anorganic Bovine Bone and Injectable Biphasic Calcium Phosphate in Humans: A Randomized Clinical Trial
AuthorMatej Tomas
MBZ: 382260
AuthorMatej Karl
AuthorMarija Čandrlić
MBZ: 374610
AuthorMarko Matijević
MBZ: 339082
AuthorMartina Juzbašić
MBZ: 382271
AuthorOlga Cvijanović Peloza
AuthorAna Terezija Jerbić Radetić
AuthorDavor Kuiš
AuthorBruno Vidaković
MBZ: 338961
AuthorZrinka Ivanišević
MBZ: 364721
AuthorŽeljka Perić Kačarević
Author's institutionUniversity of Rijeka
(Faculty of Dental Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Abstract (english)
Following trauma, chronic periapical process, or tooth extraction, a large loss of bone volume is noticed during the healing process. To facilitate the placement of dental implants, various surgical procedures are used for an optimal alveolar ridge profile, while maintaining adequate bone dimensions. The main aim of this study was to determine the healing ability (histologically and immunohistologically) of alveolar bone defects during augmentation with two different biomaterials: injectable biphasic calcium phosphate (BCP) and anorganic bovine bone (ABB). Thirty-eight subjects were randomly divided into two groups. The first group received the tested bone substitute biomaterial (BSB), i.e., BCP (maxresorb inject®), and the second group received an alternative to the gold standard, i.e., ABB (Bio-Oss®). The histopathological, histomorphometric, and immunohistochemical analyses gave comparable results for these bone substitute materials in terms of newly formed bone: (BCP: 39.91 ± 8.49%, ABB: 41.73 ± 13.99%), residual biomaterial (BCP: 28.61 ± 11.38%, ABB: 31.72 ± 15.52%), and soft tissue (BCP: 31.49 ± 11.09%, ABB: 26.54 ± 7.25%), with no significant difference found between the groups (p < 0.05, t- test), proving that BCP is equally suitable and successful for alveolar bone regeneration.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 24, no. 6, pp. 1-19, 24065539
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24065539
URN:NBNurn:nbn:hr:271:555353
Publication2023
Document URLhttp://bib.irb.hr/1261065
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-04-12 11:56:00