prikaz prve stranice dokumenta Immunohistochemical and histopathological features of persistent gingival enlargement in relation to metal allergic sensitization during orthodontic treatment
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Scientific paper - Original scientific paper
Immunohistochemical and histopathological features of persistent gingival enlargement in relation to metal allergic sensitization during orthodontic treatment
Materials (Basel), 16 (2022), 1; 81. https://doi.org/10.3390/ma16010081
Žigante, Martina; Špalj, Stjepan; Prpić, Jelena; Pavlić, Andrej; Katić, Visnja; Matušan Ilijaš, Koviljka

Institutional repository: Repository of the University of Rijeka, Faculty of Dental Medicine

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Žigante, M., Špalj, S., Prpić, J., Pavlić, A., Katić, V. & Matušan Ilijaš, K. (2022). Immunohistochemical and histopathological features of persistent gingival enlargement in relation to metal allergic sensitization during orthodontic treatment. Materials (Basel), 16. (1). doi: 10.3390/ma16010081

Žigante, Martina, et al. "Immunohistochemical and histopathological features of persistent gingival enlargement in relation to metal allergic sensitization during orthodontic treatment." Materials (Basel), vol. 16, no. 1, 2022. https://doi.org/10.3390/ma16010081

Žigante, Martina, Stjepan Špalj, Jelena Prpić, Andrej Pavlić, Visnja Katić and Koviljka Matušan Ilijaš. "Immunohistochemical and histopathological features of persistent gingival enlargement in relation to metal allergic sensitization during orthodontic treatment." Materials (Basel) 16, no. 1 (2022). https://doi.org/10.3390/ma16010081

Žigante, M., et al. (2022) 'Immunohistochemical and histopathological features of persistent gingival enlargement in relation to metal allergic sensitization during orthodontic treatment', Materials (Basel), 16(1). doi: 10.3390/ma16010081

Žigante M, Špalj S, Prpić J, Pavlić A, Katić V, Matušan Ilijaš K. Immunohistochemical and histopathological features of persistent gingival enlargement in relation to metal allergic sensitization during orthodontic treatment. Materials (Basel) [Internet]. 2022 December 22 [cited 2024 May 07];16(1). doi: 10.3390/ma16010081

M. Žigante, S. Špalj, J. Prpić, A. Pavlić, V. Katić and K. Matušan Ilijaš, "Immunohistochemical and histopathological features of persistent gingival enlargement in relation to metal allergic sensitization during orthodontic treatment", Materials (Basel), vol. 16, no. 1, December 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:271:075559. [Accessed: 07 May 2024]

Metadata
Title (english)Immunohistochemical and histopathological features of persistent gingival enlargement in relation to metal allergic sensitization during orthodontic treatment
AuthorMartina Žigante
AuthorStjepan Špalj
AuthorJelena Prpić
AuthorAndrej Pavlić
AuthorVisnja Katić
AuthorKoviljka Matušan Ilijaš
Author's institutionUniversity of Rijeka
(Faculty of Dental Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Orthodontics
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Oral Medicine
Abstract (english)
This study aimed to analyse the immunohistochemical profile of inflammatory infiltrates in the gingival tissue of patients undergoing orthodontic treatment in relation to patients’ titanium and/or nickel allergy status. Patients with gingival enlargement received initial periodontal therapy, followed by external gingivectomy in the case of persistent gingival enlargement. The sample included 44 patients (22 had metal allergic sensitisation). Histopathological changes were assessed, and an immunohistochemical analysis was performed on formalin-fixed and paraffin-embedded gingival samples using antibodies against CD1a, CD3, CD4, CD8, CD20, CD68, and CD138. Computerassisted image analysis was performed to evaluate the positive cell count in the gingival tissue. The gingiva of the sensitised patients was characterised by the absence of multifocal inflammatory infiltrates (p < 0.05), while pronounced exocytosis and band-like inflammatory infiltrates were more frequently observed in sensitised patients. In addition, there was an increase in Langerhans cells and T- helper lymphocytes and a decrease in naïve T- lymphocytes, cytotoxic T-lymphocytes, macrophages, and plasma cells in the sensitised subjects compared to non-sensitised. However, the differences were only statistically significant for macrophages, with a moderate effect size (82.8 vs. 133.9 ; p = 0.041 ; r = 0.308). The absence of multifocal inflammation appears to be the most characteristic histopathological feature of the gingiva of sensitised patients. Although their gingiva presented certain characteristics of late hypersensitivity immune reactions the observed changes imply dominant irritative effect.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMaterials (Basel)
Numberingvol. 16, no. 1, 81
e-ISSN1996-1944
DOIhttps://doi.org/10.3390/ma16010081
URN:NBNurn:nbn:hr:271:075559
Publication2022-12-22
ProjectNumber: iP-2020-02-4027
Title (croatian): Okolišni čimbenici i mikrobiološke interakcije u strukturi dentalnog biofilma
Title (english): Environmental factors and microbiological interactions in the structure of dental biofilm
Acronym: DENTALBIOFILM
Leader: Stjepan Špalj
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: IP-2014-09-7500
Title (croatian): Imunosne i regenerativne implikacije korozije dentalnih materijala u djece i adolescenata
Title (english): Immunological and regenerative implications of corrosion of dental materials in children and adolescents
Acronym: IMUNODENT
Leader: Stjepan Špalj
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: DOK-2018-01-2531
Title (croatian): Imunosne i regenerativne implikacije korozije dentalnih materijala u djece i adolescenata
Leader: Stjepan Špalj
Jurisdiction: Croatia
Funding stream: DOK
Document URLhttp://bib.irb.hr/1239633
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-01-19 13:00:08