Research objective: The aim of this study is to examine the perceptions of Quality of Life (QOL) of oncology patients among nursing students in the first and second years of their graduate studies at the university in Sveta Nedelja, focusing on their opinions about the physical, emotional, mental, and social aspects of patients' lives. Study design: A descriptive cross-sectional study. Respondents and methods: A retrospective study was conducted on the attitudes towards the QOL of oncology patients among first and second-year graduate nursing students at the Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek. The study included 70 participants and was conducted from February 9 to April 4, 2024. Data covering the physical, emotional, mental, and social dimensions of QOL were collected using an online questionnaire via Google Forms, with participants expressing their opinions through a Likert scale. Results: The study conducted among nursing students shows that 75.3% of students believe that oncology patients often experience physical pain. The majority, 91.3%, agree that patients frequently experience fatigue. Emotional challenges such as stress are highlighted by 86.7% of students, while 73% believe that patients do not have adequate access to psychological support. 78.2% of students think that patients lack sufficient social support, and a similar percentage (69.5%) believe that the illness significantly affects family relationships. Conclusion: The study results indicate that nursing students recognize significant physical and emotional challenges faced by oncology patients, including a high prevalence of pain, fatigue, and stress. They also highlight the lack of adequate emotional and social support and financial resources. It is concluded that a comprehensive educational approach is needed to address these challenges, with an emphasis on multidisciplinary collaboration and the integration of additional resources in oncology care.