Objectives: The research aims to examine the differences in sleep quality between informal caregivers and users of health care services at home. Study design: A cross-sectional was conducted.study. Participants and methods: The research was conducted at the Jadranka Plužarić Health Care Institution during February 2024. Respondents were 86 informal caregivers and 86 users. The Pittsburgh sleep quality questionnaire and the Zarit questionnaire were used. Results: Users have significantly more comorbidities than caregivers (P < 0.001). Rheumatic complaints are considerably more common in caregivers (P =0.001), and mental illnesses (P =0.003), and CVI (P =0.02) in users. Users have subjectively worse sleep quality compared to caregivers (P = 0.004). Considering the values of the overall sleep scale (0-24), all caregivers and all users are poor sleepers (score 5 and above). Users, the older they are, rated the quality of sleep (PSQI) as worse (Rho = 0.313), while there is no significant correlation between functional abilities and the sleep index. About the obtained values, it can be observed that 19 (22.1 %) caregivers have no or a slight workload, 51 (59.3 %) have a mild to moderate workload, and 16 (18.6 %) have a moderate to heavy workload. Conclusion: Informal caregivers and users are poor sleepers. No significant association of the sleep quality index with the age of informal caregivers was observed, nor with the number of months, they care for or with the number of hours per week they spend caring for a person. We associate the poorer quality of life of informal caregivers with older age, greater number of hours of care for users, and greater workload.