Romantic relationships are an important part of the lives of many people, as well as people with physical disabilities. At the same time, relationship satisfaction is an important factor which affects the functioning and duration of the relationship. Therefore, the aim of this research was to examine the effects of disability-related factors, personal factors, social factors and relationship factors on relationship satisfaction among people with physical disabilities. The research was conducted online, and the form for completion was forwarded to numerous associations for people with physical disabilities in the Republic of Croatia. The sample consisted of 101 participants. Participants completed questions related to the subjective and objective severity of disability, the Big Five Inventory-2–S (Soto and John, 2017), the Acceptance of Disability Scale (Li and Moore, 1998), Perceived Stigma (Brown, 2014), the subscales of Sexual Esteem and Sexual Depression (Snell and Papini, 1989), the Dyadic Coping Inventory (Bodenmann et al., 2018) and the Relationship Satisfaction Scale (Røysamb, Vittersø and Tambs, 2014). The results show that younger age, higher acceptance of disability, lower sexual depression and higher dyadic coping predict greater relationship satisfaction. In addition, sexual depression was a mediator for the positive relationship of acceptance of disability and relationship satisfaction, while dyadic coping proved to be a mediator in the negative relationships of relationship satisfaction with two variables, age and sexual depression. Besides having theoretical value, these results could indicate to experts who work with couples where physical disability is present which factors they can focus on in order to help them develop a satisfactory relationship.