The aim of this paper is to present museums that host projects and exhibitions which are completely or partially adapted for persons with disabilities. It focuses on a new form of communication in museum and gallery spaces, which goes beyond mere technical assistance for persons with disabilities such as installing wheelchair ramps or Braille labels for the blind and visually impaired visitors, and introduces new ways of artwork presentation adapted for persons with disabilities. The paper highlights the example of the Benozzo Gozzoli Museum in Castelfiorentino, whose collection is entirely adapted for persons with disabilities. The frescoes of the Renaissance painter Benozzo Gozzoli have been translated into relief interpretations, there are no stairs leading to the museum entrance, and the floors are connected by lifts. A video guide has been created for the deaf visitors, consisting of a recording of the deaf art historian Carlo di Biase who interprets the exhibits using the sign language. The museum is also open to persons with intellectual disabilities and autistic persons and has developed guides for them which use symbols and visual elements and constitute works of art in and of themselves. The Museo Tattile Statale Omero in Ancona also stands out by its accessibility. It was founded by the blind philosophy professor Aldo Grassini, who made sure that the whole museum collection was tactile, for the benefit of the visually impaired visitors as well as the sighted ones. In his words, this enables the blind to see and represents a new dimension of the art for the sighted. However, there are no video guides in the sign language and sign language guides are rarely hosted by the museum. Professor Aldo Grassini is also one of the rare aestheticians who addressed, in his two books, the importance of adapting the visual arts for the blind. The Florence museums have also been partially adapted for persons with disabilities, which was not a simple task as any major change in a museum posed a risk of damaging the centuries-old historical and artistic heritage. Nevertheless, they have successfully implemented new forms of communication, at least in part. This was accomplished primarily by the Uffizi Gallery, which introduced a tactile approach to artworks, as well as the Palazzo Vecchio, the Palatine Gallery with the concept of a “tactile tour”, the Modern Art Gallery of the Pitti Palace with the programme “Form and Matter through Touch” and finally the Marino Marini Museum. Among the said museums, significant solutions for deaf visitors were available only at the Marino Marini Museum. As for the selected Croatian museums, only the Typhlological Museum is entirely adapted for persons with disabilities, although its purpose is not to adapt art exhibits for such persons, but to educate the general public on their needs. 86 The selected museums in the City of Split, such as the Meštrović Gallery, the Galić Gallery and the Museum of Croatian Archaeological Monuments (MHAS), have hosted temporary exhibitions for persons with disabilities, including the examples presented in this paper: the project of the art historian Maja Šeparović of postcards for the blind and visually impaired, the “Temporary Multi-sensory Exhibition” held at the Galić Gallery and the project “In Touch with the Antiquity” presented at the MHAS. Other important examples are the successful temporary tactile exhibition of the young artist Danijela Šušak at the Typhlological Museum in Zagreb, as well the model of the Diocletian’s Palace installed in the centre of the City of Split, as a representation of urban planning adapted for the blind and visually impaired persons. Among the selected Croatian museums, almost none is adapted for the hard-of-hearing visitors, and it all comes down to hosting of sign language guides on rare occasions. With this aim, as my contribution to the change in practice, I have enclosed my original project of a Music Museum for the Deaf and Hard of Hearing, whose exhibits would serve an educational purpose by demonstrating how the deaf persons can experience individual musical elements with the help of the visual arts.