Trans* people experience discrimination in everyday life which is reflected in family dynamics after coming out, as many families go through a process of adaptation and redefinition of family relationships. The aim of this systematic review of qualitative studies is to describe the contextual determination of different dimensions of the parent-child relationship in the period following the trans* parent’s coming out to the child. In order to accomplish that aim, I set out the following research inclusion criteria: empirical qualitative research written in English, published in the period from May 1, 2017 to May 1, 2024, conducted with families in which a trans* parent came out to their child before the child turned 18 years old, as well as with a focus on the relationship between parents and children after coming out, relationship between the family and school/preschool, or recommendations for experts working in social and health fields. The results of the analysis of 21 studies included in this systematic review show that maintaining continuity in family processes, negotiating with members on decisions related to gender identity affirmation, and cooperation between parents are important for the quality of the relationship between trans* parents and their child after coming out. The results also indicate that, due to the stigmatization of these families, there are obstacles in collaboration with educational institutions. Moreover, in order to protect themselves, many families try to conceal the gender identity of trans* parents, which has implications for family processes. Recommendations for pedagogues and educators working with trans* parents, limitations of the included research, as well as directions for future research are discussed.