Behavioral immune system (BIS) is a cluster of psychological mechanisms that enable individual organisms to detect the potential presence of pathogens in their immediate environment, and to engage in behaviors that prevent contact with potentially contagious objects and individuals. Since other people are frequently the source of contagious diseases, the notion of BIS has implications for interpersonal and social behavior. In this experimental study we wanted to test if BIS has an impact on human social cognitions. Social cognition was measured as attitudes toward immigrants of the current European migrant crisis. The sample consisted of 378 subjects, divided into three groups: in the experimental group we tried to activate BIS with a newspaper article about migrants as potential carriers of various infectious diseases, in the control group the participants read a neutral text containing definitions of concepts related to migrant crisis, and in the third group the participants read a newspaper article about migrants as a socio-economic threat (thus we could differentiate whether an effect was caused specifically by BIS or rather by some general threat perception mechanism). In addition to the effect of the group, we also expected a group by gender interaction in the direction that the activation of BIS shall have larger impact on women’s than men’s attitudes. The rationale for this hypothesis was the fact that disgust is considered to be the primary emotion related to BIS, and numerous studies have shown that women are more easily disgusted than men. Neither the main hypothesis nor the interaction has been confirmed. The potential cause of such an outcome lies in the shortcomings of the study design. We have confirmed the gender difference in perceived vulnerability to disease: women perceive themselves to be more susceptible to infectious diseases and they feel stronger germ aversion as compared to men.