Anxiety sensitivity is often referred to as “fear of fear” and people with high levels of anxiety sensitivity are prone to misinterpreting anxiety symptoms as threatening. That also implies fear of bodily changes during arousal. According to the Dual Control Model (Bancroft and Janssen, 2000), a person’s sexual response depends on excitatory and inhibitory mechanisms. The aim of the study was to determine significant predictors of sexual arousal, affective sexual arousal and genital sensations and to examine the role of sexual inhibition (SIS-1) in the relationship between anxiety sensitivity and three measures of sexual arousal in women. The study involved 1,605 adult women with an average age of 32 years. Participants completed a questionnaire on the frequency of their sexual behaviors, Anxiety Sensitivity Index (ASI), Sexual Inhibition Scales/Sexual Excitation Scales short form (SIS/SES-SF) and Multiple Indicators of Subjective Sexual Arousal. Anxiety sensitivity slightly positively correlates with sexual excitation and inhibition and slightly negatively correlates with genital sensations. Significant predictors of sexual arousal are education, fantasy, frequency of intercourse, sexual arousal, and sexual inhibition (SIS-1). Significant predictors of affective sexual arousal are fantasy, frequency of intercourse, sexual arousal, and sexual inhibition (SIS-1). Significant predictors of genital sensations are education, masturbation, sexual fantasies, frequency of intercourse, sexual inhibition (SIS-1) and anxiety sensitivity. Analysis of the mediating effect of sexual inhibition (SIS-1) on the relationship between anxiety sensitivity and genital sensations revealed partial mediation.