A spinal cord injury (SCI) causes physical, psychological and social consequences and requires high adjustment of the individual in all aspects of life, and therefore in romantic relationships. The aim of this study was to examine the determinants of the quality of the intimate relationships and the differences among people with a SCI, in relation to whether they have entered a relationship, before or after the SCI. The research was conducted through an online questionnaire on a total of 129 participants aged 21-74 years (M= 43.8, SD= 11.5). The study involved 54 participants in a preinjury relationship and 75 participants in a postinjury relationship. The results show that the participants in a postinjury relationship have a statistically significant higher level of quality of life, they better accept a SCI, show a lower degree of perceived stress and greater satisfaction with the sexual aspect of the relationship compared to the participants in a preinjury relationship. No statistically significant difference was found between these two groups in the quality of the intimate relationship and anxiety and avoidance as dimensions of attachment. The results of the hierarchical regression analysis, with the control of the moment of entering the relationship (preinjury/postinjury) in the first step, showed that quality of life, non-acceptance of the SCI, perceived stress and dissatisfaction with the sexual aspect of the relationship statistically significantly contribute to explaining 46% of the variance of the quality of the intimate relationship, while the moment of entering the relationship and attachment dimensions did not prove to be significant predictors of intimate relationship quality. The obtained results indicate the need for a holistic approach to the people with SCI and potential benefit of a psychoeducation or a similar psychological intervention.