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master's thesis
Određivanje optimalnih procesnih uvjeta kod razgradnje nilotinib hidroklorida
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2020. urn:nbn:hr:149:512864
Bukvić, Silvija
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Bukvić, S. (2020). Određivanje optimalnih procesnih uvjeta kod razgradnje nilotinib hidroklorida (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:512864

Bukvić, Silvija. "Određivanje optimalnih procesnih uvjeta kod razgradnje nilotinib hidroklorida." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2020. https://urn.nsk.hr/urn:nbn:hr:149:512864

Bukvić, Silvija. "Određivanje optimalnih procesnih uvjeta kod razgradnje nilotinib hidroklorida." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2020. https://urn.nsk.hr/urn:nbn:hr:149:512864

Bukvić, S. (2020). 'Određivanje optimalnih procesnih uvjeta kod razgradnje nilotinib hidroklorida', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 May 2024, https://urn.nsk.hr/urn:nbn:hr:149:512864

Bukvić S. Određivanje optimalnih procesnih uvjeta kod razgradnje nilotinib hidroklorida [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2020 [cited 2024 May 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:512864

S. Bukvić, "Određivanje optimalnih procesnih uvjeta kod razgradnje nilotinib hidroklorida", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:149:512864

Metadata
TitleOdređivanje optimalnih procesnih uvjeta kod razgradnje nilotinib hidroklorida
Title (english)Determination of optimal process conditions for degradation of nilotinib hydrochloride
AuthorSilvija Bukvić
MentorLidija Furač (mentor)
Committee memberLidija Furač (predsjednik povjerenstva)
Committee memberMatija Cvetnić (član povjerenstva)
Committee memberDajana Kučić Grgić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2020-07-16, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U ovom radu ispitano je nekoliko značajnijih procesa razgradnje u svrhu smanjenja koncentracije farmaceutika, nilotinib hidroklorida u vodi pri različitim uvjetima. Nilotinib hidroklorid pripada skupini specifičnih inhibitora enzima tirozin kinaze, a upotrebljava se za liječenje kronične mijeloične leukemije. Korišteni postupci razgradnje su hidroliza, prisilna razgradnja oksidansom, fotoliza te fotooksidacija. Dobiveni rezultati pokazuju da je svaka od navedenih metoda pogodna za razgradnju nilotinib hidroklorida. Korištenjem agresivnijih metoda koje se temelje na UV zračenju, različitim oksidansima ili njihovim kombinacijama dobiven je veliki broj novih produkata različitih karakteristika. Za određivanje optimalnih uvjeta razgradnje nilotinib hidroklorida korištena je metoda Taguchi dizajna. Utjecaji pojedinih parametara za razgradnju, određeni su matematičkim modeliranjem. Rezultati pokazuju slab utjecaj oksidansa i pH zbog izuzetne stabilnosti molekule nilotinib hidroklorida. Uvjeti koji znatno pogoduju razgradnji nilotinib hidroklorida su visoka koncentracija kloridnih iona te kombinacija visoke koncentracije fosfata i niske koncentracije sulfata.
Abstract (english)
In this paper, several significant degradation processes were investigated in order to reduce the concentration of pharmaceuticals, nilotinib hydrochloride in water under different conditions. Nilotinib hydrochloride belongs to a group of specific tyrosine kinase enzyme inhibitors and is used to treat chronic myeloid leukemia. The decomposition methods used are hydrolysis, forced oxidative decomposition, photolysis and photooxidation. The results obtained show that each of these methods is suitable for the degradation of nilotinib hydrochloride. By using more aggressive methods based on UV radiation, different oxidants or their combinations, a large number of new products with different characteristics were obtained. The Taguchi design method was used to determine the optimal degradation conditions of nilotinib hydrochloride. The influences of individual parameters for degradation were determined by conducting mathematical modeling. The results show a weak effect of oxidants and pH due to the exceptional stability of the nilotinib hydrochloride molecule. Conditions that are significantly conducive to the degradation of nilotinib hydrochloride are high concentrations of chloride ions and a combination of high phosphate concentrations and low sulfate concentrations.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:512864
ProjectNumber: IP-2014-09-7992
Title: Modeliranje okolišnih aspekata napredne obrade voda za razgradnju prioritetnih onečišćivala
Title: Modeling of environmental aspects of advanced water treatment for fegradation of priority pollutants
Acronym: MEAoWT
Leader: Tomislav Bolanča
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Applied Chemistry - Graduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Applied organic chemistry
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra primijenjene kemije (magistar/magistra primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2022-02-28 18:06:35