prikaz prve stranice dokumenta Zelena sinteza konjugata kinolina i ferocena primjenom mehanokemije
Embargo period 2025-01-01
master's thesis
Zelena sinteza konjugata kinolina i ferocena primjenom mehanokemije
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2020. urn:nbn:hr:149:141486
Čipor, Ivona
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Čipor, I. (2020). Zelena sinteza konjugata kinolina i ferocena primjenom mehanokemije (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:141486

Čipor, Ivona. "Zelena sinteza konjugata kinolina i ferocena primjenom mehanokemije." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2020. https://urn.nsk.hr/urn:nbn:hr:149:141486

Čipor, Ivona. "Zelena sinteza konjugata kinolina i ferocena primjenom mehanokemije." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2020. https://urn.nsk.hr/urn:nbn:hr:149:141486

Čipor, I. (2020). 'Zelena sinteza konjugata kinolina i ferocena primjenom mehanokemije', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:141486

Čipor I. Zelena sinteza konjugata kinolina i ferocena primjenom mehanokemije [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2020 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:149:141486

I. Čipor, "Zelena sinteza konjugata kinolina i ferocena primjenom mehanokemije", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:149:141486

Metadata
TitleZelena sinteza konjugata kinolina i ferocena primjenom mehanokemije
Title (english)Green synthesis of quinoline and ferrocene conjugates using mechanochemistry
AuthorIvona Čipor
MentorSilvana Raić-Malić (mentor)
Committee memberSilvana Raić-Malić (predsjednik povjerenstva)
Committee memberSilvija Maračić (član povjerenstva)
Committee memberŠime Ukić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2020-07-16, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U ovom radu opisana je sinteza novih konjugata 1,1'-disupstituiranih ferocena i kinolina povezanih 1,2,3-triazolilnom poveznicom (4a–d, 5a–d, 6a, 6b, 7a i 7b). 6-supstituirani derivati kinolona 1a–1d priređeni su Conrad-Limpachovom sintezom te su nadalje prevedeni u O- i N-propargilirane derivate kinolina, odnosno kinolona 2a–2d. Ciljani konjugati 1,1'-disupstituiranih ferocena i kinolina, odnosno kinolona 4a–d, 5a–d, 6a, 6b, 7a i 7b priređeni su bakrom(I) kataliziranom azid-alkin cikloadicijom propargiliranih derivata 2a–2d, 3a i 3b i bis-azidnih derivata ferocena u mehanokemijiskim uvjetima. Strukture novosintetiziranih spojeva potvrđene su 1H NMR i 13C NMR spektroskopijom, a naknadno će se provesti i antiproliferativna ispitivanja novosintetiziranih spojeva.
Abstract (english)
In this work the syntesis of novel 1,1’-disubstituted ferrocene quinoline derivatives bridged via 1,2,3-triazole linker (4a–d, 5a–d, 6a, 6b, 7a and 7b) is described. 6-Substituted quinolone derivatives 1a–1d were prepared by the Conrad-Limpach method and further transformed to O- and N-propargylated derivatives 2a–2d. The target 1,1'-disubstituted ferrocene and quinoline or quinolone conjugates 4a–d, 5a–d, 6a, 6b, 7a and 7b were prepared by copper(I) catalysed azide-alkyne cycloaddition of propargylated derivatives 2a–2d, 3a and 3b with corresponding bis-azidoferrocene derivatives. The structures of all compounds were determined by 1H NMR and 13C NMR spectroscopy. Antiproliferative evaluations of these compounds will be performed.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:141486
ProjectNumber: IP-2018-01-4682
Title: Novi spojevi temeljeni na bioizosterima purina za ispitivanje njihovih antitumorskih i antipatogenih djelovanja
Acronym: PurBioCaPa
Leader: Silvana Raić-Malić
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Applied Chemistry - Graduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Applied organic chemistry
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra primijenjene kemije (magistar/magistra primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsEmbargoed access
Embargo expiration date: 2025-01-01
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Created on2022-03-01 17:59:18