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master's thesis
Optimizacija procesa kristalizacije fosamprenavir-kalcija
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2020. urn:nbn:hr:149:374407
Đuran, Luka
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Đuran, L. (2020). Optimizacija procesa kristalizacije fosamprenavir-kalcija (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:374407

Đuran, Luka. "Optimizacija procesa kristalizacije fosamprenavir-kalcija." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2020. https://urn.nsk.hr/urn:nbn:hr:149:374407

Đuran, Luka. "Optimizacija procesa kristalizacije fosamprenavir-kalcija." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2020. https://urn.nsk.hr/urn:nbn:hr:149:374407

Đuran, L. (2020). 'Optimizacija procesa kristalizacije fosamprenavir-kalcija', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 03 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:374407

Đuran L. Optimizacija procesa kristalizacije fosamprenavir-kalcija [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2020 [cited 2024 November 03] Available at: https://urn.nsk.hr/urn:nbn:hr:149:374407

L. Đuran, "Optimizacija procesa kristalizacije fosamprenavir-kalcija", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:149:374407

Metadata
TitleOptimizacija procesa kristalizacije fosamprenavir-kalcija
Title (english)Optimization of the crystallization process for fosamprenavir calcium
AuthorLuka Đuran
MentorJasna Prlić Kardum (mentor)
Committee memberJasna Prlić Kardum (predsjednik povjerenstva)
Committee memberAleksandra Sander (član povjerenstva)
Committee memberNenad Bolf (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2020-09-30, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Farmaceutska industrija svakodnevno koristi procese kristalizacije za pripremu djelatnih tvari korištenih u medicinske svrhe. Fosamprenavir i njegove soli značajni su u borbi protiv virusa humane imunodeficijencije, što čini poznavanje njihovih metoda pripreme i karakterizacije od izrazite važnosti. U ovom radu ispitane su različite metode kristalizacije djelatne tvari fosamprenavir-kalcija, kao i odabir pogodnih otapala i antiotapala te njihov utjecaj na granulometrijska svojstva i polimorfiju kristala. Utvrđeno je da metoda kristalizacije uz dodatak antiotapala pokazuje veču učinkovitost od metode kristalizacije hlađenjem za ispitane sustave otapala, te da su kristali dobiveni metodom uz dodatak antiotapala prikladniji za daljnje separacijske procese. Ustanovljeno je da se iskorištenje veće od 90 % ostvaruje pri dodavanju 36 % volumnog udjela vode ispitivanim smjesama otapala. Različiti procesni uvjeti, kao i korištena otapala, imali su značajan utjecaj na pojavu smjese polimorfnih oblika fosamprenavir-kalcija, što je utvrđeno analizom rendgenske difrakcije dobivenih kristala.
Abstract (english)
Using crystallization processes for development of active pharmaceutical ingredients (API) used for medicinal purposes is commonplace in the pharmaceutical industry. Fosamprenavir and its salts show importance in treating the symptoms of human immunodefficiency virus infections, which makes their methods of preparation and characterization of great significance. In this research different methods of crystallization of fosamprenavir calcium, suitable solvents and antisolvents and their effect on crystal granulometric properties and polimorfy were investigated. Antisolvent crystallization was shown to be more efficient than cooling crystallization for all investigated solvent mixtures, and crystals produced with antisolvent method were found to be preferable for further separation processes. Procces efficiency of over 90 % for 36 % volume fraction of antisolvent added to solvent mixtures was shown. Presence of polymorfic mixtures in the prepared crystals was significantly influenced by operating conditions and chosen solvent mixtures, as was found in X-ray diffraction analysis.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:374407
Study programmeTitle: Chemical Engineering - Graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2022-03-02 12:37:55