prikaz prve stranice dokumenta Strukturna karakterizacija selenijem dopiranih kalcijevih fosfata Rietveldovom metodom utočnjavanja
  Download
PDF 9.42 MB
master's thesis
Strukturna karakterizacija selenijem dopiranih kalcijevih fosfata Rietveldovom metodom utočnjavanja
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2020. urn:nbn:hr:149:757198
Ivanković, Klaudija
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Ivanković, K. (2020). Strukturna karakterizacija selenijem dopiranih kalcijevih fosfata Rietveldovom metodom utočnjavanja (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:757198

Ivanković, Klaudija. "Strukturna karakterizacija selenijem dopiranih kalcijevih fosfata Rietveldovom metodom utočnjavanja." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2020. https://urn.nsk.hr/urn:nbn:hr:149:757198

Ivanković, Klaudija. "Strukturna karakterizacija selenijem dopiranih kalcijevih fosfata Rietveldovom metodom utočnjavanja." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2020. https://urn.nsk.hr/urn:nbn:hr:149:757198

Ivanković, K. (2020). 'Strukturna karakterizacija selenijem dopiranih kalcijevih fosfata Rietveldovom metodom utočnjavanja', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 23 June 2024, https://urn.nsk.hr/urn:nbn:hr:149:757198

Ivanković K. Strukturna karakterizacija selenijem dopiranih kalcijevih fosfata Rietveldovom metodom utočnjavanja [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2020 [cited 2024 June 23] Available at: https://urn.nsk.hr/urn:nbn:hr:149:757198

K. Ivanković, "Strukturna karakterizacija selenijem dopiranih kalcijevih fosfata Rietveldovom metodom utočnjavanja", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:149:757198

Metadata
TitleStrukturna karakterizacija selenijem dopiranih kalcijevih fosfata Rietveldovom metodom utočnjavanja
Title (english)Structural characterization of selenium substituted calcium phosphates by Rietveld refainment method
AuthorKlaudija Ivanković
MentorHrvoje Ivanković (mentor)
Committee memberHrvoje Ivanković (predsjednik povjerenstva)
Committee memberStjepan Milardović (član povjerenstva)
Committee memberMarica Ivanković (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2020-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Lomovi, oštećenja i razne deformacije kostiju uslijed bolesti ili traume, mogu rezultirati sporim oporavkom, višegodišnjim zdravstvenim problemima i financijskim izdacima. Stoga, zadaća inženjerstva koštanog tkiva jest ponuditi nova rješenja u zacjeljivanju kostiju, potičući prirodni nastanak nove kosti. Zbog svoje biokompatibilnosti, mogućnosti biorazgradnje, osteoinduktivnosti i sličnosti s biološkim apatitom, hidroksiapatit je najkorišteniji materijal u inženjerstvu koštanog tkiva. Kako selenij pokazuje antibakterijska i protutumorska svojstva te je važan u održavanju mineralne gustoće kostiju, cilj je sintetizirati kalcijev fosfatni sustav koji sadrži hidroksiapatit dopiran selenitnim ionima. Metodom precipitacije, iz vodene otopine sintetizirani su uzorci kalcijevih fosfata dopirani s 0, 1, 5 i 10 % selenitnih iona, gdje je korišteni kalcit biogenog izvora. Uzorci su karakterizirani rendgenskom difrakcijskom analizom, Rietveldovom metodom utočnjavanja, infracrvenom spektroskopijom s Fourierovom transformacijom te induktivno spregnutom plazmom sa spektrometrom masa. Morfologija je praćena uz pomoć pretražnog elektronskog mikroskopa. Rezultati pokazuju uspješno dopiranje kalcijevog fosfatnog sustava selenitom. Dopiranje ovim ionima dovodi do formiranja aglomerata, gubitka prvobitne pločaste strukture hidroksiapatita i smanjenja kristalnosti uzorka. Sintetizirani uzorci su toplinski nestabilni. Kod toplinske obrade pri 1200 ℃, selenij ne zaostaje u uzorku, kristalnost sustava je veća nego kod tek sintetiziranih uzorka, a stabilnost HAp faze raste povećanjem udjela dopiranja.
Abstract (english)
Fractures, lesions and various bone deformations due to illness or trauma can result in slow recovery, years of health problems and great financial costs. Therefore, the task of bone tissue engineering is to offer new solutions in bone healing process by promoting the natural formation of new bone. Due to its biocompatibility, biodegradability, osteoinductivity and similarity to biological apatite, hydroxyapatite is considered the gold standard in the bone tissue engineering. Selenium shows antibacterial and anticancer properties and is an essential component in maintaining bone mineral density, so the aim of the research is to synthesize a calcium phosphate system that contains hydroxyapatite doped with selenite. With precipitation method from aquatic solution, calcium phosphate samples doped with 0, 1, 5 and 10 % selenite were synthesized, in which the used calcite was biomimetic. The samples were characterized by X-ray powder diffraction, Rietveld refinement, Fourier transform infrared spectroscopy and inductively coupled plasma mass spectrometry. The morphology was determined by scanning electron microscope. The results show successful doping of the calcium phosphate systems with selenite. The doping of this system with selenite ions leads to the formation of agglomerates, the loss of the original plate-like structure and decrease in crystallinity. Synthesized samples show lack of thermal stability. When thermally annealed at 1200 ℃, selenium does not lag behind, crystallinity is improved compared to as-prepared samples, and stability of HAp correlates positively with the selenite content.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:757198
ProjectNumber: IP-2014-09-3752
Title: Razvoj biokompatibilnih materijala na temelju hidroksiapatita za primjene u inženjerstvu koštanog tkiva
Title: Development of Biocompatible Hydroxyapatite Based Materials for Bone Tissue Engineering Applications
Acronym: HaTEA
Leader: Hrvoje Ivanković
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Applied Chemistry - Graduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Applied organic chemistry
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra primijenjene kemije (magistar/magistra primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-03-03 09:45:52