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master's thesis
Sinteza i karakterizacija novih oksimskih derivata heterostilbena kao potencijalnih reaktivatora kolinesteraza
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2020. urn:nbn:hr:149:944501
Puček, Ivana
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Puček, I. (2020). Sinteza i karakterizacija novih oksimskih derivata heterostilbena kao potencijalnih reaktivatora kolinesteraza (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:944501

Puček, Ivana. "Sinteza i karakterizacija novih oksimskih derivata heterostilbena kao potencijalnih reaktivatora kolinesteraza." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2020. https://urn.nsk.hr/urn:nbn:hr:149:944501

Puček, Ivana. "Sinteza i karakterizacija novih oksimskih derivata heterostilbena kao potencijalnih reaktivatora kolinesteraza." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2020. https://urn.nsk.hr/urn:nbn:hr:149:944501

Puček, I. (2020). 'Sinteza i karakterizacija novih oksimskih derivata heterostilbena kao potencijalnih reaktivatora kolinesteraza', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:944501

Puček I. Sinteza i karakterizacija novih oksimskih derivata heterostilbena kao potencijalnih reaktivatora kolinesteraza [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2020 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:944501

I. Puček, "Sinteza i karakterizacija novih oksimskih derivata heterostilbena kao potencijalnih reaktivatora kolinesteraza", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:149:944501

Metadata
TitleSinteza i karakterizacija novih oksimskih derivata heterostilbena kao potencijalnih reaktivatora kolinesteraza
Title (english)Synthesis and characterization of novel oxime derivatives of heterostilbenes as potential cholinesterase reactivators
AuthorIvana Puček
MentorIrena Škorić (mentor)
Committee memberIrena Škorić (predsjednik povjerenstva)
Committee memberDragana Vuk (član povjerenstva)
Committee memberSandra Babić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2020-09-29, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U cilju proučavanja djelovanja oksimskih derivata heterostilbena kao reaktivatora kolinesteraza sintetizirani su novi spojevi 15 – 21. Dobivanje željenih spojeva započinje Wittigovom reakcijom kojom su sintetizirani heterostilbeni 1 – 7, koji su Vilsmeier-Haackovim formiliranjem prevedeni u aldehide 8 – 14. Na njima je provedena reakcija u cilju dobivanja oksimskih derivata 15 – 21, koji do sada literaturno nisu poznati. Očekivani produkti bili su cis- i trans- izomeri spojeva 15 – 21, s nizom različitih supstituenata vezanih u para- položaju benzenskog prstena. U konačnici, u svakoj provedenoj reakciji dobivanja oksima nastala su četiri izomera, s obzirom na konfiguraciju dvostruke veze ugljika, te s obzirom na konfiguraciju dvostruke veze između ugljika i dušika oksimske skupine. Svaki dobiveni oksimski derivat 15 – 21 može zauzeti četiri različita izomerna oblika: cis, syn-, trans, syn-, cis, anti-, trans, anti-. Svi novi spojevi okarakterizirani su spektroskopskim metodama, a za one dobivene u dovoljnoj količini bit će ispitana reaktivacijska aktivnost prema humanim enzimima AChE i BChE.
Abstract (english)
For the purpose of studying the effect of oxime derivatives of heterostilbene as a cholinesterase reactivators, new compounds 15 – 21 were synthesized. Starting ompounds 1 – 7 were synthesized using the Wittig reaction, and they are converted to the aldehydes 8 – 14 by Vilsmeier-Haack formylation. In order to obtain previously unknown oximes 15 – 21, oximation was carried out. The expected products were the cis- and trans- isomers of compounds 15 – 21, which contain different substituents bound in the para-position of the benzene ring. Finally, in each reaction of oxime formation, four isomers were obtained, considering to the configuration of the carbon-carbon double bond, and to the double bond between the carbon and nitrogen of the oxime group. Each obtained oxime derivative 15 – 21 can take four different isomeric forms: cis, syn-, trans, syn-, cis, anti-, trans, anti-. All new compounds were characterized by spectroscopic methods, and for those obtained in sufficient quantities, the reactivation activity against human enzymes AChE and BChE will be tested.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:944501
Study programmeTitle: Applied Chemistry - Graduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Applied organic chemistry
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra primijenjene kemije (magistar/magistra primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2022-03-07 16:51:26