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master's thesis
Određivanje optimalnih uvjeta razgradnje farmaceutika u vodi naprednim oksidacijskim procesima
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2020. urn:nbn:hr:149:541902
Tolić, Ana
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Tolić, A. (2020). Određivanje optimalnih uvjeta razgradnje farmaceutika u vodi naprednim oksidacijskim procesima (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:541902

Tolić, Ana. "Određivanje optimalnih uvjeta razgradnje farmaceutika u vodi naprednim oksidacijskim procesima." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2020. https://urn.nsk.hr/urn:nbn:hr:149:541902

Tolić, Ana. "Određivanje optimalnih uvjeta razgradnje farmaceutika u vodi naprednim oksidacijskim procesima." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2020. https://urn.nsk.hr/urn:nbn:hr:149:541902

Tolić, A. (2020). 'Određivanje optimalnih uvjeta razgradnje farmaceutika u vodi naprednim oksidacijskim procesima', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 25 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:541902

Tolić A. Određivanje optimalnih uvjeta razgradnje farmaceutika u vodi naprednim oksidacijskim procesima [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2020 [cited 2024 December 25] Available at: https://urn.nsk.hr/urn:nbn:hr:149:541902

A. Tolić, "Određivanje optimalnih uvjeta razgradnje farmaceutika u vodi naprednim oksidacijskim procesima", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:149:541902

Metadata
TitleOdređivanje optimalnih uvjeta razgradnje farmaceutika u vodi naprednim oksidacijskim procesima
Title (english)AOP degradation of pharmaceuticals in water: determination of optimal conditions
AuthorAna Tolić
MentorŠime Ukić (mentor)
Committee memberŠime Ukić (predsjednik povjerenstva)
Committee memberMatija Cvetnić (član povjerenstva)
Committee memberLidija Furač (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2020-09-29, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Farmaceutici su sintetski proizvodi neizostavni u svakodnevnoj upotrebi. Smatra se da je trenutno u uporabi oko 3000 farmaceutski aktivnih supstanci, a procjenjuje se da će do 2023. više od 50 novih farmaceutika doći na tržište. Stoga, njihov unos time i akumulacija u okolišu raste što može imati negativne posljedice na cjelokupni ekosustav. U ovom radu istražena je razgradnja 4 različita farmaceutika: desvenlafaksina, donepezil hidroklorida, hidroklortiazida i omeprazola naprednim oksidacijskim procesima fotooksidacije, UV/H2O2 i UV/PS. U svrhu procjene utjecaja procesnih parametara (pH, koncentracija oksidansa i vrsta radikala) na razgradnju farmaceutika korištenjem metode površine odziva razvijeni su modeli. Statističkom analizom utvrđeno je da su razvijeni modeli značajni i točni. Modeli zadovoljavaju kriterije R^2 > 0,9, R^2adj > 0,9 p < 0,05. Razgradnja istraženih farmaceutika kinetici prvog reda bez obzira na strukturne razlike kroz čitav niz ispitivanih parametara procesa. Rezultati su ukazali da je kinetika razgradnje desvenlafaksina, donepezil hidroklorida te hidroklortiazida veća u UV/PS nego u UV/H2O2 procesu. Vrijednosti kinetike degradacije omeprazola UV/H2O2 procesom veće su od kinetike UV/PS procesa.
Abstract (english)
Pharmaceuticals are indispensable components in everyday use and their use is constantly growing. Approximately 3000 pharmaceutically active substances are currently in use and it has been estimated that by 2023, more than 50 new pharmaceuticals will be on the market. Consequently, their accumulation and quantity in the environment increases which can have negative consequences on the whole ecosystem. In this study, the degradations of 4 different pharmaceuticals (desvenlafaxine, donepezil hydrochloride, hydrochlorothiazide and omeprazole) by photooxidation, UV/H2O2 and UV/PS processes were observed. The influences of process parameters (pH, oxidant concentration and type of radical) on the degradation were studied using the response surface methodology. Statistical analysis showed that the developed models are significant and accurate. The models meet the criteria R^2 > 0.9, R^2adj > 0.9 p < 0.05. It was found that the degradation obeys the first order kinetics regardless of the structural differences throughout the examined process parameters. The results indicated that degradation kinetics of desvenlafaxine, donepezil hydrochloride and hydrochlorothiazide were higher in case of UV/PS process than in case UV/H2O2 process. The degradation kinetics of the omeprazole UV/H2O2 process was higher than the kinetics of the UV/PS process.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:541902
ProjectNumber: IP-2014-09-7992
Title: Modeliranje okolišnih aspekata napredne obrade voda za razgradnju prioritetnih onečišćivala
Title: Modeling of environmental aspects of advanced water treatment for fegradation of priority pollutants
Acronym: MEAoWT
Leader: Tomislav Bolanča
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Applied Chemistry - Graduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Environmental chemistry and green technologies
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra primijenjene kemije (magistar/magistra primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-04-20 12:19:44